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Review
. 2024 Dec 13;4(1):100140.
doi: 10.1016/j.iliver.2024.100140. eCollection 2025 Mar.

Emerging role of natural bioactive compounds in navigating the future of liver disease

Neha Chaudhary  1 , Muhammad Arif  1 , Sheeba Shafi  2 , Shom Prakash Kushwaha  1 , Pushpendra Soni  1
Affiliations
Review

Emerging role of natural bioactive compounds in navigating the future of liver disease

Neha Chaudhary et al. ILIVER. .

Abstract

Liver diseases, including liver inflammation, fatty liver disease, cirrhosis, and hepatocellular carcinoma, represent significant global health challenges. Traditional treatments often emphasize symptom management, leading to increased interest in natural bioactive compounds for their potential therapeutic benefits. This review examines the role of natural bioactive compounds in managing hepatic disorders, with a particular focus on their mechanisms of action and supporting clinical evidence. Compounds such as curcumin, silymarin, resveratrol, triterpenoids, apigenin, and delphinidin derivatives have demonstrated promising hepatoprotective effects in preclinical studies, largely due to their anti-inflammatory, antioxidant, and anti-fibrotic properties. Nevertheless, further research is necessary to determine optimal dosing, safety profiles, and long-term effects. Understanding the mechanisms of action and therapeutic potential of these bioactive compounds may provide critical insights into their role in the treatment of hepatic diseases.

Keywords: Alcohol-associated hepatic disease; Autoimmune hepatitis; Hepatoprotective; Medicine-induced hepatic injury; Nonalcoholic fatty hepatic disease; Resveratrol; Viral hepatitis.

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Conflict of interest statement

All authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Causes of liver diseases and potential remedies with potent hepatoprotective medicinal plants.
Fig. 2
Fig. 2
Medicinal plants with hepatoprotective properties. (A) Aegle marmelos. (B) Silybum marianum. (C) Cynara scolymus. (D) Curcuma longa. (E) Taraxacum officinale. (F) Aloe vera. (G) Zingiber officinale. (H) Glycyrrhiza glabra. (I) Panax ginseng. (J) Alchornea cordifolia. (K) Cassia fistula. (L) Clitoria ternatea. (M) Ficus religiosa. (N) Ginkgo biloba. (O) Hypericum japonicum. (P) Phyllanthus niruri.
Fig. 3
Fig. 3
Natural bioactive compounds targeting liver disease.
See this image and copyright information in PMC

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