Restrictive Oxygen Use Did Not Improve Outcomes in the UK ROX Study

Editorial

. 2025 Aug;69(7):e70098.

doi: 10.1111/aas.70098.

Affiliations

¹ Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
² Intensive Care Unit, Liverpool Hospital, South Western Sydney Local Health District and Southwestern Clinical School, University of New South Wales, Sydney, Australia.

Editorial

Markus B Skrifvars et al. Acta Anaesthesiol Scand. 2025 Aug.

. 2025 Aug;69(7):e70098.

doi: 10.1111/aas.70098.

¹ Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
² Intensive Care Unit, Liverpool Hospital, South Western Sydney Local Health District and Southwestern Clinical School, University of New South Wales, Sydney, Australia.

No abstract available

Conflict of interest statement

The authors declare no conflicts of interest.

1. Møller M. H., Granholm A., Alhazzani W., et al., “Higher Versus Lower Oxygenation Targets in Adult ICU Patients: A Rapid Practice Guideline,” Acta Anaesthesiologica Scandinavica 68 (2024): 302–310, 10.1111/aas.14332. - DOI - PubMed
1. Singer M., Young P. J., Laffey J. G., et al., “Dangers of Hyperoxia,” Critical Care 25 (2021): 440, 10.1186/s13054-021-03815-y. - DOI - PMC - PubMed
1. Crescioli E., Krejberg K. U., Klitgaard T. L., et al., “Long‐Term Effects of Lower Versus Higher Oxygenation Levels in Adult ICU Patients: A Systematic Review,” Acta Anaesthesiologica Scandinavica 66 (2022): 910–922, 10.1111/aas.14107. - DOI - PMC - PubMed
1. ICU‐ROX investigators and Australian and New Zealand Intensive Care Society Clinical Trials Group , “Conservative Oxygen Therapy During Mechanical Ventilation in the ICU,” New England Journal of Medicine 382 (2020): 989–998, 10.1056/NEJMoa1903297. - DOI - PubMed
1. Schjørring O. L., Klitgaard T. L., Perner A., et al., “Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure,” New England Journal of Medicine 384 (2021): 1301–1311, 10.1056/NEJMoa2032510. - DOI - PubMed