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. 2025 Oct 1;46(37):3663-3666.
doi: 10.1093/eurheartj/ehaf397.

Short-term benefit of early rhythm control for atrial fibrillation: the EAST-AFNET 4 trial

Julius Obergassel  1   2   3   4 , Anna Suling  5 , Katrin Borof  1 , Alan John Camm  6 , Harry J G M Crijns  7 , Lars Eckardt  8   9 , Larissa Fabritz  1   2   3   4   9   10 , Andreas Goette  9   11   12 , Märit Jensen  13 , Marc Daniel Lemoine  1   2   3 , Christina Magnussen  1   3   14 , Andreas Metzner  1   3 , Andreas Rillig  1   3 , Ulrich Schotten  9   15 , Renate Schnabel  1   3 , Götz Thomalla  13 , Panos Vardas  16   17 , Reza Wakili  18   19 , Stephan Willems  20 , Antonia Zapf  5 , Paulus Kirchhof  1   2   3   10 , Benedikt Schrage  1   3   14
Affiliations

Short-term benefit of early rhythm control for atrial fibrillation: the EAST-AFNET 4 trial

Julius Obergassel et al. Eur Heart J. .
No abstract available

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Figures

Figure 1
Figure 1
Use of treatments, primary outcomes, and safety outcomes within 30 days after randomization in the overall study cohort from the EAST-AFNET 4 trial
See this image and copyright information in PMC

References

    1. Van Gelder IC, Rienstra M, Bunting KV, Casado-Arroyo R, Caso V, Crijns HJGM, et al. 2024 ESC guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J 2024;45:3314–414. 10.1093/eurheartj/ehae176 - DOI - PubMed
    1. Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J 2021;42:373–498. 10.1093/eurheartj/ehaa612 - DOI - PubMed
    1. Kirchhof P, Camm AJ, Goette A, Brandes A, Eckardt L, Elvan A, et al. Early rhythm-control therapy in patients with atrial fibrillation. N Engl J Med 2020;383:1305–16. 10.1056/NEJMoa2019422 - DOI - PubMed
    1. Willems S, Borof K, Brandes A, Breithardt G, Camm AJ, Crijns HJGM, et al. Systematic, early rhythm control strategy for atrial fibrillation in patients with or without symptoms: the EAST-AFNET 4 trial. Eur Heart J 2022;43:1219–30. 10.1093/eurheartj/ehab593 - DOI - PMC - PubMed
    1. Rillig A, Magnussen C, Ozga AK, Suling A, Brandes A, Breithardt G, et al. Early rhythm control therapy in patients with atrial fibrillation and heart failure. Circulation 2021;144:845–58. 10.1161/CIRCULATIONAHA.121.056323 - DOI - PMC - PubMed