Ovarian tissue autotransplantation in acute leukemia: balancing the risk of relapse and the hope of parenthood

Florian Chevillon¹, Elsa Labrune², Emmanuelle Clappier³, Hélène Lapillonne⁴, Paola Ballerini⁴, Virginie Barraud Lange⁵, Anne Fortin⁶, Raphael Itzykson⁷, Gérard Socié⁸, Agnès Buzyn⁹, Guy Leverger¹⁰, Jean-Hugues Dalle¹¹, Nathalie Dhédin¹², Nicolas Boissel¹², Régis Peffault De Latour⁸, Bruno Salle¹³, Christophe Roux¹⁴, Catherine Poirot¹⁵

Affiliations

¹ Hematology for Adolescents and Young Adults, Hôpital Saint Louis, AP-HP, Paris, France; GRECOT (Groupe de Recherche et d'Étude sur la Cryoconservation de l'Ovaire et du Testicule). Florian.chevillon@aphp.fr.
² GRECOT (Groupe de Recherche et d'Étude sur la Cryoconservation de l'Ovaire et du Testicule); Reproductive Biology, Hospices civils de Lyon, Lyon.
³ Hematology Biology, Hôpital Saint Louis, AP-HP, Paris.
⁴ Hematology Biology, Hôpital Trousseau, AP-HP, Paris.
⁵ Hematology for Adolescents and Young Adults, Hôpital Saint Louis, AP-HP, Paris, France; GRECOT (Groupe de Recherche et d'Étude sur la Cryoconservation de l'Ovaire et du Testicule); Reproductive Biology, Hôpital Port Royal, AP-HP, Paris.
⁶ Gynecology and Obstetrics, Clinique Metivet, 94100 Saint Maur des Fossés.
⁷ Hematology, Hôpital Saint Louis, AP-HP, Paris.
⁸ Department of Stem Cell Transplantation, Hôpital Saint Louis, AP-HP, Paris.
⁹ Hematology, Hôpital Saint Antoine, AP-HP, Paris.
¹⁰ Hematology, Hôpital Trousseau, AP-HP, Paris.
¹¹ Hematology, Hôpital Robert Debré, AP-HP, Paris.
¹² Hematology for Adolescents and Young Adults, Hôpital Saint Louis, AP-HP, Paris.
¹³ Reproductive Biology, Hospices civils de Lyon, Lyon.
¹⁴ GRECOT (Groupe de Recherche et d'Étude sur la Cryoconservation de l'Ovaire et du Testicule); Reproductive Biology, Centre hospitalier Régional Universitaire de Besançon, Besançon.
¹⁵ Hematology for Adolescents and Young Adults, Hôpital Saint Louis, AP-HP, Paris, France; GRECOT (Groupe de Recherche et d'Étude sur la Cryoconservation de l'Ovaire et du Testicule).

PMID: 40637728
PMCID: PMC12951168
DOI: 10.3324/haematol.2025.287942

Ovarian tissue autotransplantation in acute leukemia: balancing the risk of relapse and the hope of parenthood

Florian Chevillon et al. Haematologica. 2026.

. 2026 Mar 1;111(3):1044-1048.

doi: 10.3324/haematol.2025.287942. Epub 2025 Jul 10.

Authors

Affiliations

¹ Hematology for Adolescents and Young Adults, Hôpital Saint Louis, AP-HP, Paris, France; GRECOT (Groupe de Recherche et d'Étude sur la Cryoconservation de l'Ovaire et du Testicule). Florian.chevillon@aphp.fr.
² GRECOT (Groupe de Recherche et d'Étude sur la Cryoconservation de l'Ovaire et du Testicule); Reproductive Biology, Hospices civils de Lyon, Lyon.
³ Hematology Biology, Hôpital Saint Louis, AP-HP, Paris.
⁴ Hematology Biology, Hôpital Trousseau, AP-HP, Paris.
⁵ Hematology for Adolescents and Young Adults, Hôpital Saint Louis, AP-HP, Paris, France; GRECOT (Groupe de Recherche et d'Étude sur la Cryoconservation de l'Ovaire et du Testicule); Reproductive Biology, Hôpital Port Royal, AP-HP, Paris.
⁶ Gynecology and Obstetrics, Clinique Metivet, 94100 Saint Maur des Fossés.
⁷ Hematology, Hôpital Saint Louis, AP-HP, Paris.
⁸ Department of Stem Cell Transplantation, Hôpital Saint Louis, AP-HP, Paris.
⁹ Hematology, Hôpital Saint Antoine, AP-HP, Paris.
¹⁰ Hematology, Hôpital Trousseau, AP-HP, Paris.
¹¹ Hematology, Hôpital Robert Debré, AP-HP, Paris.
¹² Hematology for Adolescents and Young Adults, Hôpital Saint Louis, AP-HP, Paris.
¹³ Reproductive Biology, Hospices civils de Lyon, Lyon.
¹⁴ GRECOT (Groupe de Recherche et d'Étude sur la Cryoconservation de l'Ovaire et du Testicule); Reproductive Biology, Centre hospitalier Régional Universitaire de Besançon, Besançon.
¹⁵ Hematology for Adolescents and Young Adults, Hôpital Saint Louis, AP-HP, Paris, France; GRECOT (Groupe de Recherche et d'Étude sur la Cryoconservation de l'Ovaire et du Testicule).

PMID: 40637728
PMCID: PMC12951168
DOI: 10.3324/haematol.2025.287942

No abstract available

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References

1. Sanders JE, Hawley J, Levy W, et al. Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation. Blood. 1996;87(7):3045-3052. - PubMed
1. Poirot C, Fortin A, Dhédin N, et al. Post-transplant outcome of ovarian tissue cryopreserved after chemotherapy in hematological malignancies. Haematologica. 2019;104(8):e360-e363. - PMC - PubMed
1. Dolmans MM, von Wolff M, Poirot C, et al. Transplantation of cryopreserved ovarian tissue in a series of 285 women: a review of five leading European centers. Fertil Steril. 2021;115(5):1102-1115. - PubMed
1. Dolmans MM, Marinescu C, Saussoy P, Langendonckt AV, Amorim C, Donnez J. Reimplantation of cryopreserved ovarian tissue from patients with acute lymphoblastic leukemia is potentially unsafe. Blood. 2010;116(16):2908-2914. - PubMed
1. Jahnukainen K, Tinkanen H, Wikström A, et al. Bone marrow remission status predicts leukemia contamination in ovarian biopsies collected for fertility preservation. Leukemia. 2013;27(5):1183-1185. - PubMed

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Ovarian tissue autotransplantation in acute leukemia: balancing the risk of relapse and the hope of parenthood

Affiliations

Ovarian tissue autotransplantation in acute leukemia: balancing the risk of relapse and the hope of parenthood

Authors

Affiliations

References

LinkOut - more resources

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