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Meta-Analysis
. 2025 Jul 4;71(5):e20241480.
doi: 10.1590/1806-9282.20241480. eCollection 2025.

Health outcomes of umbilical cord clamping techniques in preterm neonates: meta-analysis

Fatma Şule Bilgiç  1 , Aysu Yıldız Karaahmet  2 , Altan Alaybeyoğlu  3
Affiliations
Meta-Analysis

Health outcomes of umbilical cord clamping techniques in preterm neonates: meta-analysis

Fatma Şule Bilgiç et al. Rev Assoc Med Bras (1992). .

Abstract

Objective: The aim of this study was to determine the effect of umbilical cord clamping time and milking on blood parameters in preterm neonates.

Methods: A literature search was conducted between July and September 2024 in four databases. The search was performed using MeSH-based keywords.

Results: In this study, the results of 14 studies covering a total of 1,609 preterm neonates were analyzed. Follow-up after intervention showed no statistically significant difference in hemoglobin (standardized mean difference=0.22, 95%CI 0.04-0.48, Z=1.65, p=0.10) and bilirubin (standardized mean difference=0.22, 95%CI 0.30-0.74, Z=0.82, p=0.41) between the groups. There was a statistically significant difference in ferritin (standardized mean difference=0.73, 95%CI 0.30-1.15, Z=3.37, p=0.00008) and hematocrit (standardized mean difference=0.30, 95%CI 0.05-0.54, Z=2.41, p=0.02) values, and the effect size was positive. According to the subgroup analysis of the combined results of the studies, it was seen that there was no statistically significant difference in the adverse health outcomes in preterms (OR 0.92, 95%CI 0.74-1.15, Z=0.72, p=0.47).

Conclusion: From the analysis, it can be observed that late cord clamping and cord milking can prevent premature anemia by increasing hematocrit and ferritin formation in preterm newborns.

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Conflict of interest statement

Conflicts of interest: the authors declare there is no conflicts of interest.

Figures

Figure 1
Figure 1. Forest plot for comparison: meta-analysis results on the effect of interventions on hematological parameters.
Figure 2
Figure 2. Forest plot of comparison: meta-analysis results on the effect of interventions on preterm health outcomes.
See this image and copyright information in PMC

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