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. 2025 Jul 7:67:e43.
doi: 10.1590/S1678-9946202567043. eCollection 2025.

Serology survey of chikungunya virus in high-risk pregnant women and placental tissue findings

Thamirys Cosmo Grillo Fajardo  1 , Antonio Carlos de Quadros Junior  1 , Clóvis Antonio Lopes Pinto  2   3 , Geovane Ribeiro Dos Santos  2 , Andrea Cristina Botelho da Silva  1 , Daniel Thome Catalan  1 , Ana Paula Antunes Pascalicchio Bertozzi  4   5 , Rosa Estela Gazeta  4   5 , Antonio Fernandes Moron  6   7 , Saulo Duarte Passos  1   4   5 ; Jundiai Zika Cohort Group; Alexandra Siqueira Mello  5 , Antoni Soriano-Arandes  5 , Ana Alarcon  5 , Alfredo Garcia-Alix  5 , Alify Bertoldo da Silva  5 , Dora Fix Ventura  5 , Danielle Bruna Leal de Oliveira  5 , Danilla Soares Tambalo  5 , Diego da Silva Lima  5 , Dirce Takako Fujiwara  5 , Edison Luiz Durigon  5 , Eduardo Roberto Bagne  5 , Fernanda Guerra Velasco  5 , Luiz Claudio Portnoi Baran  5 , Fernando Novo Arita  5 , Francisco Del Moral Hernandez  5 , Juliana Paula Gomes de Almeida  5 , Karen Richter Camandulli  5 , Lucas Pires de Castro  5 , Márcia Borges Machado  5 , Mayana Zatz  5 , Maria Manoela Duarte Rodrigues  5 , Maria de Fátima Valente Rizzo  5 , Maria Amélia Farrão  5 , Mirella Nayane Barbosa Leite  5 , Nemésio Florence Filho  5 , Patrícia Carvalho Loiola  5 , Raquel Prestes  5 , Rita de Cássia Aguirre Dezena  5 , Sandra Helena Alves Bonon  5 , Sergio Vranjac  5 , Sérgio Rosemberg  5 , Stephanno Gomes Pereira Sarmento  5 , Steven Sol Witkinchi  5 , Tathiana Ghisi de Souza  5 , Viviane Cristina Martori Pandini  5 , Viviam Paschoarelli Paiva  5
Affiliations

Serology survey of chikungunya virus in high-risk pregnant women and placental tissue findings

Thamirys Cosmo Grillo Fajardo et al. Rev Inst Med Trop Sao Paulo. .

Abstract

Evidence suggests a risk of maternal transmission of chikungunya virus (CHIKV) during the first and third trimesters, potentially leading to miscarriage or neurological consequences for the fetus. This study aimed to conduct a serological survey for CHIKV among women with high-risk pregnancies and analyze neonatal variables and placental tissue alterations. From March 2016 to April 2021, serological, histological, and molecular tests for CHIKV were performed. Blood samples were analyzed for anti-CHIKV IgG and IgM antibodies, and placental tissue was examined for CHIKV RNA and histological changes. Among pregnant patients, 1.33% (7/526) had reactive IgG, and 0.38% (2/526) had IgM/IgG-type antibodies during delivery. Although placental histology of CHIKV disease showed alterations, no viral genetic material was identified in the analyzed tissues. Therefore, further research is needed, including the use of complementary diagnostic techniques, to better understand the impact of this relatively new disease among high-risk pregnant women and newborns.

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Conflict of interest statement

CONFLICT OF INTERESTS: The authors declare no conflict of interest.

Figures

Figure 1
Figure 1. Flowchart of participants during clinical trial.
See this image and copyright information in PMC

References

    1. Bonifay T, Douine M, Bonnefoy C, Hurpeau B, Nacher M, Djossou F, et al. Poverty and outbreaks: when chikungunya virus hits more precarious populations than dengue virus in French Guiana. Open Forum Infect Dis. 2017;4:ofx247. - PMC - PubMed
    1. Fernández-Salas I, Díaz-González EE, López-Gatell H, Alpuche-Aranda C. Chikungunya and Zika virus dissemination in the Americas: different arboviruses reflecting the same spreading routes and poor vector-control policies. Curr Opin Infect Dis. 2016;29:467–475. - PubMed
    1. Musso D, Rodriguez-Morales AJ, Levi JE, Cao-Lormeau VM, Gubler DJ. Unexpected outbreaks of arbovirus infections: lessons learned from the Pacific and tropical America. Lancet Infect Dis. 2018;18:e355–e361. - PubMed
    1. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente Monitoramento das arboviroses e balanço de encerramento do Comitê de Operações de Emergência (COE) Dengue e outras Arboviroses 2024. [cited 2025 Mar 20];Bol Epidemiol. 2024 55:1–31. https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/boletins...
    1. Charlier C, Beaudoin MC, Couderc T, Lortholary O, Lecuit M. Arboviruses and pregnancy: maternal, fetal, and neonatal effects. Lancet Child Adolesc Health. 2017;1:134–146. - PubMed

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