Replacing microglia to treat a brain disease

Siling Du^{1

2}, Jonathan Kipnis^{1

2}

Affiliations

¹ Brain Immunology and Glia Center, School of Medicine, Washington University in St Louis, St Louis, MO, USA.
² Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.

Comment

Siling Du et al. Science. 2025.

. 2025 Jul 10;389(6756):129-130.

doi: 10.1126/science.adz0113. Epub 2025 Jul 10.

Siling Du^{1

2}, Jonathan Kipnis^{1

2}

¹ Brain Immunology and Glia Center, School of Medicine, Washington University in St Louis, St Louis, MO, USA.
² Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.

Abstract

Swapping out the brain's immune cells can slow progression of a devastating neurological disease.

Microglia replacement halts the progression of microgliopathy in mice and humans.
Wu J, Wang Y, Li X, Ouyang P, Cai Y, He Y, Zhang M, Luan X, Jin Y, Wang J, Xiao Y, Liang Y, Xie F, Shu Y, Hu J, Chang C, Jiang J, Wu D, Zhao Y, Liu T, Li Y, Huang X, Li Y, Zhang J, Cao Y, Cheng X, Mao Y, Rao Y, Cao L, Peng B. Wu J, et al. Science. 2025 Jul 10;389(6756):eadr1015. doi: 10.1126/science.adr1015. Epub 2025 Jul 10. Science. 2025. PMID: 40638739