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. 2025 Jul 9;33(7):1050-1051.
doi: 10.1016/j.chom.2025.06.012.

A helping hand against severe dengue

Shirin Kalimuddin  1 , Eng Eong Ooi  2
Affiliations

A helping hand against severe dengue

Shirin Kalimuddin et al. Cell Host Microbe. .

Abstract

What immune responses protect against severe dengue? In this issue of Cell Host & Microbe, Gonnella et al. find that early CD4+ TEMRA cell expansion, enhanced regulatory T cell function, and type I IFN signatures in T cells are associated with protection, offering insights with implications for dengue vaccine development.

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Conflict of interest statement

Declaration of interests S.K. and E.E.O. have served in advisory capacities on dengue to Takeda Pharmaceuticals and Johnson & Johnson. E.E.O. has served in advisory capacities on dengue to Sanofi Pasteur, MSD (Merck), and Novartis.

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