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. 2025 Jul 8:S2468-6530(25)00313-6.
doi: 10.1016/j.oret.2025.07.003. Online ahead of print.

Topographic Features in Retinopathy of Prematurity With en Face Ultra-Widefield OCT

David A Sutter  1 , Mani K Woodward  1 , John Jackson  1 , Yakub Bayhaqi  1 , Aaron S Coyner  1 , Shuibin Ni  1 , Susan Ostmo  1 , Michael F Chiang  2 , Benjamin K Young  1 , Yifan Jian  1 , John Peter Campbell  3
Affiliations

Topographic Features in Retinopathy of Prematurity With en Face Ultra-Widefield OCT

David A Sutter et al. Ophthalmol Retina. .

Abstract

Purpose: This study presents 2 methods of en face visualization enabled by ultra-widefield (UWF) OCT, which provide topographic information of retinopathy of prematurity (ROP) without requiring direct visualization of cross-sectional scans.

Design: Evaluation of diagnostic technology.

Subjects: Infants undergoing ROP screening at Oregon Health Science University between June 2023 and October 2024, who consented to research imaging.

Methods: An investigational contact-based UWF-OCT captured 800 × 800 A-scans. Max intensity projections (MIP) were constructed, from the highest intensity pixel in each A-scan's x-y coordinate plane. Retinal thickness maps (RTMs) were generated by first segmenting the retina with a previously trained U-net, then calculating the retinal thickness at each position in microns, and displaying it with a topographic colormap.

Main outcome measures: Cross-sectional and longitudinal qualitative evaluation of the diagnostic utility of MIP and RTM across the spectrum of ROP stage.

Results: MIP highlights areas of high signal attenuation, such as blood vessels and the atypical neurovascular thickening accompanying stage 1 or greater ROP. Retinal thickness maps reflect thickness information in the retina that highlights complementary aspects of the progression and spectrum of the stage. Retinal thickness maps also reveal subclinical elements of ROP morphology, such as the foveal contour, in some cases "stage 0" ROP, and cystoid macular edema.

Conclusions: This study presents 2 techniques to visualize pathology in ROP from UWF-OCT. Together, they enable both high-contrast visualization of the vascular features of ROP and the associated topographic changes across the spectrum of ROP.

Financial disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Keywords: Retinopathy of prematurity; Retinovascular disease; Ultra-widefield OCT.

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Conflict of interest statement

Disclosures

J. Peter Campbell: Siloam Vision: Code O, Genentech: Code C

Yifan Jian: Siloam Vision: Code O

OHSU, J. P. Campbell, and Y Jian have a financial interest in Siloam Vision, that may have a commercial interest in the results of this research and technology. This potential conflict of interest has been reviewed and managed by OHSU

References

    1. 1 T-TP, Ni S, Ostmo S, et al. Association of Optical Coherence Tomography–Measured Fibrovascular Ridge Thickness and Clinical Disease Stage in Retinopathy of Prematurity. JAMA Ophthalmol. 2022;140:1121. - PMC - PubMed
    1. Maldonado RS, O’Connell RV., Sarin N, et al. Dynamics of Human Foveal Development after Premature Birth. Ophthalmology. 2011;118:2315–2325. - PMC - PubMed
    1. O’Sullivan ML, Ying G-S, Mangalesh S, et al. Foveal Differentiation and Inner Retinal Displacement Are Arrested in Extremely Premature Infants. Investigative Opthalmology & Visual Science. 2021;62:25. - PMC - PubMed
    1. Burt SS, Coyner AS, Roti EV., et al. Automated Quantification of Retinopathy of Prematurity Stage via Ultrawidefield OCT. Ophthalmology Science. 2025;5:100663. - PMC - PubMed
    1. Jackson J, Woodward M, Coyner A. U-Net-derived automated ultra-widefield retinal vessel segmentation using swept-source optical coherence tomography images. Invest Ophthalmol Vis Sci. 2023;64.

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