Elevated Levels of Extracellular Vesicle-Associated TAOK1 in Plasma: A Diagnostic Marker for Cognitive Decline in Parkinson's Disease Dementia and Alzheimer's Disease

Pin-Jui Kung¹, Yi-Tzang Tsai², Rwei-Ling Yu³, Hsiang-Hsuan Lin-Wang², Ming-Che Kuo^{4

5}, Chia-Ching Wu⁶, Chien-Tai Hong^{7

8}, Koji Ueda⁹, Shau-Ping Lin^{1

2

10

11}, Ruey-Meei Wu^{4

12}

Affiliations

¹ Genome and Systems Biology Degree Program, National Taiwan University and Academia Sinica, Taipei, Taiwan.
² Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
³ Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁴ Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
⁵ Department of Medicine, National Taiwan University Cancer Center, Taipei, Taiwan.
⁶ Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁷ Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
⁸ Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
⁹ Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
¹⁰ Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan.
¹¹ Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan.
¹² Department of Neurology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.

Pin-Jui Kung et al. Mov Disord. 2025 Oct.

. 2025 Oct;40(10):2269-2271.

doi: 10.1002/mds.30287. Epub 2025 Jul 11.

¹ Genome and Systems Biology Degree Program, National Taiwan University and Academia Sinica, Taipei, Taiwan.
² Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
³ Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁴ Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
⁵ Department of Medicine, National Taiwan University Cancer Center, Taipei, Taiwan.
⁶ Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁷ Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
⁸ Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
⁹ Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
¹⁰ Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan.
¹¹ Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan.
¹² Department of Neurology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.

No abstract available

Figures

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1. Hsu YF, Lin SP, Chu YT, et al. Plasma miR‐203a‐3p as a novel predictor of dementia in patients with Parkinson's disease. Int J Mol Sci 2024;25(6):3554. - PMC - PubMed
1. Tavares IA, Touma D, Lynham S, et al. Prostate‐derived sterile 20‐like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle‐bearing neurons in Alzheimer disease. J Biol Chem 2013;288:15418–15429. - PMC - PubMed
1. Morris JC, Storandt M, Miller JP, et al. Mild cognitive impairment represents early‐stage Alzheimer disease. Arch Neurol 2001;58:397–405. - PubMed
1. Giacomini C, Koo CY, Yankova N, et al. A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies. Acta Neuropathol Commun 2018;6(1):37. - PMC - PubMed