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. 1977 Jun;22(3):835-8.
doi: 10.1128/JVI.22.3.835-838.1977.

Metabolism of uracil-containing DNA: degradation of bacteriophage PBS2 DNA in Bacillus subtilis

B K Duncan, H R Warner

Metabolism of uracil-containing DNA: degradation of bacteriophage PBS2 DNA in Bacillus subtilis

B K Duncan et al. J Virol. 1977 Jun.

Abstract

When Bacillus subtilis is infected by the uracil-containing DNA phage PBS2, the parental DNA labeled with radioactive uracil and cytosine remains acid insoluble. If the synthesis of the phage-induced uracil-DNA N-glycosidase inhibitor is prevented, the parental DNA is completely degraded to acid-soluble products beginning at about 6 min after infection. The host N-glycosidase probably initiates the degradation pathway, with nucleases being responsible for the remaining degradation of the DNA.

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References

    1. Nature. 1976 Jan 1-8;259(5538):64-6 - PubMed
    1. Proc Natl Acad Sci U S A. 1958 Jul 15;44(7):633-40 - PubMed
    1. Nature. 1963 Feb 23;197:794-5 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Jan;74(1):154-7 - PubMed
    1. J Virol. 1976 Nov;20(2):535-8 - PubMed

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