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. 2025 Jul;7(4):e250189.
doi: 10.1148/rycan.250189.

Gastric Medullary Carcinoma

Saumya Gurbani  1 , Courtney Wiley  1 , Raul Gonzalez  2
Affiliations

Gastric Medullary Carcinoma

Saumya Gurbani et al. Radiol Imaging Cancer. 2025 Jul.
No abstract available

Keywords: Abdomen/GI; Neoplasms-Primary; Stomach.

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Conflict of interest statement

Disclosures of conflicts of interest: S.G. Institutional funds for attending meetings such as the Radiological Society of North America Annual Meeting; member of the Radiology: Imaging Cancer trainee editorial board. C.W. No relevant relationships. R.G. No relevant relationships.

Figures

Images in an 82-year-old male patient with gastric medullary carcinoma. (A) Coronal contrast-enhanced CT image of the abdomen and pelvis demonstrates irregular enhancement and thickening of the gastric antral wall (purple arrows) with focus of ulceration (red arrows). (B) Image from fluoroscopic upper gastrointestinal series shows a corresponding filling defect at the gastric antrum (yellow arrows).
Figure 1:
Images in an 82-year-old male patient with gastric medullary carcinoma. (A) Coronal contrast-enhanced CT image of the abdomen and pelvis demonstrates irregular enhancement and thickening of the gastric antral wall (purple arrows) with focus of ulceration (red arrows). (B) Image from fluoroscopic upper gastrointestinal series shows a corresponding filling defect at the gastric antrum (yellow arrows).
(A) Photomicrograph of gastric medullary carcinoma shows sheets of cells with large nuclei and prominent cytoplasm (red arrows) with accompanying inflammatory stroma (yellow arrows). (Hematoxylin-eosin stain; original magnification, ×40.) (B) Photomicrographs for MutL homolog 1 (MLH1) and postmeiotic segregation increased 2 (PMS2) show loss of expression of both proteins in tumor cells, with retained expression in inflammatory and endothelial cells. (Immunohistochemical stain; original magnification, ×40.)
Figure 2:
(A) Photomicrograph of gastric medullary carcinoma shows sheets of cells with large nuclei and prominent cytoplasm (red arrows) with accompanying inflammatory stroma (yellow arrows). (Hematoxylin-eosin stain; original magnification, ×40.) (B) Photomicrographs for MutL homolog 1 (MLH1) and postmeiotic segregation increased 2 (PMS2) show loss of expression of both proteins in tumor cells, with retained expression in inflammatory and endothelial cells. (Immunohistochemical stain; original magnification, ×40.)
See this image and copyright information in PMC

References

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