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Review
. 2025 Jun 29;14(13):995.
doi: 10.3390/cells14130995.

Immunotherapy for Platinum-Resistant Ovarian Cancer as a Glimmer of Hope

Jan Brancewicz  1 , Irena Barbara Padzińska-Pruszyńska  2 , Małgorzata Kubiak  2 , Paulina Kucharzewska  2
Affiliations
Review

Immunotherapy for Platinum-Resistant Ovarian Cancer as a Glimmer of Hope

Jan Brancewicz et al. Cells. .

Abstract

Ovarian cancer is a leading cause of cancer-related deaths among women, with platinum resistance posing a significant challenge. Conventional therapies often fail in these cases, highlighting the urgent need for novel treatment approaches. Immunotherapy has emerged as a promising strategy, offering renewed hope for patients with platinum-resistant ovarian cancer (PROC). This review explores the current landscape of immunotherapies for PROC, discussing different approaches, their mechanisms of action, and the potential for overcoming the limitations of conventional treatments.

Keywords: cancer immunotherapy; cell-based therapies; ovarian cancer; tumor microenvironment; tumor-associated macrophages.

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Conflict of interest statement

Author Jan Brancewicz was employed by the company Cellis AG. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The company had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Factors driving the development of platinum resistance in OC cells. Created using BioRender.com.
Figure 2
Figure 2
Timeline of key milestones in the rise of OC immunotherapy.
Figure 3
Figure 3
Most promising immunotherapies for OC in development.
See this image and copyright information in PMC

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