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Case Reports
. 2025 Oct;175(13-14):309-310.
doi: 10.1007/s10354-025-01095-7. Epub 2025 Jul 7.

Periocular purpura as a manifestation of amyloid light-chain amyloidosis

Daniel Craus  1 , Alexander Kreuter  2   3   4 , Frederik Bertling  5 , Stela Theodoropoulou  6 , Valentina Laura Müller  1
Affiliations
Case Reports

Periocular purpura as a manifestation of amyloid light-chain amyloidosis

Daniel Craus et al. Wien Med Wochenschr. 2025 Oct.

Abstract

This report emphasizes the importance of a thorough clinical examination for detecting bilateral periocular purpura, a key clinical hallmark of amyloid light-chain (AL) amyloidosis. Amyloid light-chain amyloidosis, often secondary to plasma cell dyscrasia, results from amyloid light-chain deposition, potentially leading to multiorgan involvement with progressive damage. Diagnosis relies on histopathology with Congo red staining, serum protein studies, and bone marrow analysis. Early recognition and treatment of the underlying hematologic malignancy are crucial for improving patient outcomes.

Keywords: Amyloid light-chain amyloidosis; Congo red staining; Plasma cell dyscrasia; Raccoon sign.

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Conflict of interest statement

Declarations. Conflict of interest: D. Craus, A. Kreuter, F. Bertling, S. Theodoropoulou, and V.L. Müller declare that they have no competing interests. Ethical standards: For this article no studies with human participants or animals were performed by any of the authors. All studies cited were in accordance with the ethical standards indicated in this case. Additional written informed consent was obtained from the patient for publishing this article, also for publication of the identifying information.

References

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