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Review
. 2025 Jul 3;17(13):2239.
doi: 10.3390/cancers17132239.

Next-Generation Therapies in Mantle Cell Lymphoma (MCL): The Evolving Landscape in Treatment of Relapse/Refractory After CAR-T Cells

Elia Boccellato  1 , Lorenzo Comba  1   2 , Rita Tavarozzi  3   4 , Claudia Castellino  1 , Myriam Foglietta  1 , Daniele Mattei  1 , Marco Ladetto  3   4 , Massimo Massaia  1   5 , Alessia Castellino  1   5
Affiliations
Review

Next-Generation Therapies in Mantle Cell Lymphoma (MCL): The Evolving Landscape in Treatment of Relapse/Refractory After CAR-T Cells

Elia Boccellato et al. Cancers (Basel). .

Abstract

Mantle cell lymphoma (MCL) is a rare but heterogeneous subtype of non-Hodgkin lymphoma (NHL) with a prognosis ranging from very favorable in indolent cases to a poor prognosis for more aggressive variants [...].

Keywords: bispecific antibodies; mantle cell lymphoma; monoclonal antibodies; post-CART; relapsed/refractory.

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Conflict of interest statement

E.B.: honoraria from Astrazeneca, Amgen, Beigene, Mayo Clinic, travel grants from Kyowa Kirin. M.L.: reports consulting fees from Astrazeneca, Beigene, Janssen and Lilly. Honoraria for lectures, speaker’s bureaus or educational events from Astrazeneca, Beigene, Janssen and Lilly. Participation on data safety monitoring board with Acerta. C.A. speaker’s bureau and travel grant from Takeda. Honoraria for lectures from Taked and Novartis. A.C.: travel grant from Kyowa Kirin and Kite, spearker’s bureau from Roche and Kite. R.T.: honoraria from Lilly and Janssen. M.F.: honoraria from Astrazeneca, travel grant from Kite. M.M., L.C. and D.M. declare no conflict of interest.

Figures

Figure 1
Figure 1
Main therapeutic targets and active drugs under investigation in mantle cell lymphoma.
Figure 2
Figure 2
Proposed therapeutic algorithm for mantle cell lymphoma including both clinically available and experimental drugs, expected in the near future. Abbreviations—BR: bendamustine rituximab; BCL: B-cell lymphoma; BTKi: Bruton tyrosine kinase inhibitor; CAR-T: chimeric antigen receptor-T cell; R: rituximab.
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