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. 2025 Jun 27;30(13):2768.
doi: 10.3390/molecules30132768.

Cochlospermum angolense Welw ex Oliv: Phytochemical Profile, Antioxidant Activity, and Therapeutic Prospects

Nsevolo Samba  1   2   3 , Abdy Morales Barrios  4   5 , Estela Guerrero De León  4   5 , Cesar Raposo  6 , Radhia Aitfella Lahlou  1   3   7 , Joana Curto  1   3 , Jesus M Rodilla  1   3 , Alejandro M Roncero  8 , David Diez  8 , Lúcia Silva  1   3
Affiliations

Cochlospermum angolense Welw ex Oliv: Phytochemical Profile, Antioxidant Activity, and Therapeutic Prospects

Nsevolo Samba et al. Molecules. .

Abstract

The phytochemical investigation and evaluation of the antioxidant activity of the leaves, bark, and roots of Cochlospermum angolense Welw ex Oliv-a valued plant that is widely used in traditional Angolan medicine-hold significant importance. Compounds were extracted from the aforementioned plant using acetone and ethanol and identified by HPLC-ESI-MSn. Both extracts demonstrated notable abilities to scavenge 2,2-diphenyl-1-picrylhydrazyl, nitric oxide, and superoxide radicals, as well as to inhibit lipid peroxidation. A HPLC analysis revealed a diverse array of bioactive compounds, including flavonoids, phenols, alkaloids, quinones, and terpenes, which help neutralize free radicals and protect cells against oxidative stress, thereby contributing to the prevention of various diseases. Moreover, the acetone and ethanol extracts proved to be excellent sources of antioxidants. For the first time, the present study identified new compounds never reported in this species, such as (+)-abscisic acid, angustine B, pinobanksin, dihydrogenistein, (-)-8-prenylnaringenin, isoquercetin, samandarine, dihydromyricetin, and eupatoriocromene, in the leaves, bark, and roots, marking a significant advance in the chemical characterization of C. angolense. These findings enhance our understanding of the bioactive phytochemicals and antioxidant properties of C. angolense and open new avenues for future therapeutic and pharmacological research, further supporting its traditional use in Angolan medicine.

Keywords: Cochlospermum angolense; HPLC-ESI-MSn; antioxidant activity; bark; leaves; roots.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
HPLC-ESI-MSn Chromatograms of Cochlospermum angolense extracts. (A) Acetone extract of the leaves; (B) Ethanolic extract of leaves; (C) Acetone extract of barks; (D) Ethanolic extract of barks; (E) Acetone extract of roots; (F) Ethanolic extract of roots.
Figure 2
Figure 2
Angolan Cochlospermum angolense Welw ex Oliv.
Figure 3
Figure 3
The topography of Angola, indicating provincial boundaries and region of study.
See this image and copyright information in PMC

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