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Review
. 2025 Jun 23;26(13):6000.
doi: 10.3390/ijms26136000.

Perspectives on the Parathyroid-Thymus Interconnection-A Literature Review

Maria-Paula Comănescu  1 , Otilia Boișteanu  2 , Delia Hînganu  3 , Marius Valeriu Hînganu  3 , Roxana Grigorovici  4 , Alexandru Grigorovici  1
Affiliations
Review

Perspectives on the Parathyroid-Thymus Interconnection-A Literature Review

Maria-Paula Comănescu et al. Int J Mol Sci. .

Abstract

The parathyroid and thymus glands are key components of the endocrine and immune systems, respectively, with intriguing developmental, anatomical, and functional interrelationships. This study starts from the hypothesis that, given their shared embryological origin, it is plausible that the thymus and parathyroid glands interact functionally and may share pathological pathways. The present study explores the developmental pathways, spatial proximity, and potential cross-talk between these glands. Recent studies suggest that parathyroid hormone (PTH) may influence thymic function, including T-cell maturation and immune regulation, while thymic signaling molecules could impact calcium homeostasis and parathyroid activity. Understanding the functional and etiopathogenical relations between these endocrine glands offers new insights into endocrine-immunological crosstalk, and therapeutic approaches targeting disorders such as hypoparathyroidism, thymomas, myasthenia gravis and thymic hypoplasia. Perspectives and conclusion: Future research is essential to discover the molecular mechanisms underpinning this dynamic interrelation and its broader implications for health and disease. Because there is still very little data on this interaction, in-depth studies are necessary on large groups of patients. This research proposes a cross-study of the receptors for the main substances secreted by the two categories of endocrine glands. At the same time, it is essential to carry out an in-depth study on the cervico-pericardial ligaments through the lens of this glandular interaction. These ligaments could contain the main blood and nerve communication pathway between the parathyroids and the glands.

Keywords: morfofunctional endocrine research; parathyroid glands; parathyroid–thymus interconnection; thymic function.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The thymus and parathyroid domains are separated from each other by less well-understood mechanisms, but involvement of neural crest cells prompts thymus migration, dragging along the inferior parathyroid glands. This representation is based on currently available experimental studies, although certain anatomical pathways remain hypothetical.
Figure 2
Figure 2
Functional communication pathways between parathyroid and thymus glands; dashed lines indicate proposed or hypothetical interactions not yet fully supported by experimental evidence. The illustrated mechanism is proposed as a conceptual model and has not yet been fully validated in vivo.
Figure 3
Figure 3
Physio–pathological correlation between parathyroid and thymus glands. This representation is based on currently available experimental studies, although certain anatomical pathways remain hypothetical.
See this image and copyright information in PMC

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