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Review
. 2025 Jun 28;26(13):6272.
doi: 10.3390/ijms26136272.

NT-proBNP and BNP as Biomarkers for Preeclampsia: A Systematic Review and Meta-Analysis

Viorela-Elena Suciu  1 , Daniel-Corneliu Leucuța  2 , Andrei Mihai Măluțan  1 , Cristian Iuhas  1 , Mihaela Oancea  1 , Carmen Elena Bucuri  1   3 , Maria Patricia Roman  1 , Cristina Ormindean  1 , Dan Mihu  1 , Răzvan Ciortea  1
Affiliations
Review

NT-proBNP and BNP as Biomarkers for Preeclampsia: A Systematic Review and Meta-Analysis

Viorela-Elena Suciu et al. Int J Mol Sci. .

Abstract

The aim of this study was to evaluate and synthesize the existing evidence on N-terminal pro-brain natriuretic peptide (NT-proBNP) and brain natriuretic peptide (BNP) as biomarkers for preeclampsia as compared with a healthy pregnant group, but also comparing them in early-onset preeclampsia (EOP) versus late-onset preeclampsia (LOP). Five electronic databases, PubMed, EMBASE, Web of Science, Scopus, and LILACS, were searched for studies on pregnant women comparing NT-proBNP and BNP levels in preeclampsia vs. healthy pregnancies and EOP vs. LOP. From the 752 identified records, 31 studies were included in the review, referring to 3915 participants. When comparing PE to healthy pregnancies and EOP to LOP, there was a considerable increase in NT-proBNP levels in the PE group, respectively, in EOP: 206.19 pg/mL (95% CI 139.68-272.69) (p ≤ 0.001) in the PE group, and 182.42 pg/mL (95% CI 99.65-265.19) (p ≤ 0.001) in the EOP group. Regarding BNP, the levels were higher in the PE group (30.13 (95% CI 17.22-43.04), p ≤ 0.001), respectively in the EOP group (33.35 pg/mL (95% CI 20.26-46.43), p ≤ 0.001). NT-proBNP and BNP levels are consistently elevated in preeclampsia compared to healthy pregnancies and in EOP compared to LOP.

Keywords: biomarkers; brain natriuretic peptide; preeclampsia.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA flowchart reporting identification, screening, selection, and inclusion of studies in the systematic review.
Figure 2
Figure 2
NT-proBNP mean difference meta-analysis between preeclampsia and healthy patients. NT, N terminal; BNP, brain natriuretic peptide; SD, standard deviation; MD, mean difference; CI, confidence interval [28,29,30,31,32,33,34,35,36,39,40,42,43,44].
Figure 3
Figure 3
NT-proBNP comparison between early-onset preeclampsia (EOP) and late-onset preeclampsia (LOP). NT, N terminal; BNP, brain natriuretic peptide; SD, standard deviation; MD, mean difference; CI, confidence interval [14,28,31,34,35,36,38,41,42,44].
Figure 4
Figure 4
BNP mean difference meta-analysis between preeclampsia and healthy patients. BNP, brain natriuretic peptide; SD, standard deviation; MD, mean difference; CI, confidence interval [16,17,18,19,20,21,22,23,24,26,45].
Figure 5
Figure 5
BNP comparison between early-onset preeclampsia (EOP) and late-onset preeclampsia (LOP). BNP, brain natriuretic peptide; SD, standard deviation; MD, mean difference; CI, confidence interval [20,25].
See this image and copyright information in PMC

References

    1. Roberts J.M. Preeclampsia epidemiology(ies) and pathophysiology(ies) Best Pract. Res. Clin. Obs. Gynaecol. 2024;94:102480. doi: 10.1016/j.bpobgyn.2024.102480. - DOI - PubMed
    1. Melchiorre K., Giorgione V., Thilaganathan B. The placenta and preeclampsia: Villain or victim? Am. J. Obstet. Gynecol. 2022;226:954–962. doi: 10.1016/j.ajog.2020.10.024. - DOI - PubMed
    1. Ives C.W., Sinkey R., Rajapreyar I., Tita A.T.N., Oparil S. Preeclampsia-Pathophysiology and Clinical Presentations: JACC State-of-the-Art Review. J. Am. Coll. Cardiol. 2020;76:1690–1702. doi: 10.1016/j.jacc.2020.08.014. - DOI - PubMed
    1. Alese M.O., Moodley J., Naicker T. Preeclampsia and HELLP syndrome, the role of the liver. J. Matern. Fetal Neonatal Med. 2021;34:117–123. doi: 10.1080/14767058.2019.1572737. - DOI - PubMed
    1. Turbeville H.R., Sasser J.M. Preeclampsia beyond pregnancy: Long-term consequences for mother and child. Am. J. Physiol. Ren. Physiol. 2020;318:F1315–F1326. doi: 10.1152/ajprenal.00071.2020. - DOI - PMC - PubMed

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