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Editorial
. 2025 Jul 11;6(7):100772.
doi: 10.1016/j.medj.2025.100772.

Aldosterone synthase inhibition in mineralocorticoid blockade: From hypertension to cardiovascular and kidney disease

Jonathan W Cunningham  1 , Carolyn S P Lam  2
Affiliations
Editorial

Aldosterone synthase inhibition in mineralocorticoid blockade: From hypertension to cardiovascular and kidney disease

Jonathan W Cunningham et al. Med. .

Abstract

The Advance-HTN trial demonstrated that lorundrostat, an aldosterone synthase inhibitor, effectively reduced 24-h systolic blood pressure by 8 mm Hg in resistant hypertension, with manageable hyperkalemia.1 These findings support further research into aldosterone synthase inhibitors as promising alternatives to mineralocorticoid receptor antagonists for resistant hypertension management.

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Conflict of interest statement

Declaration of interests J.W.C. reports personal consulting fees from Us2.ai, Occlutech, and Edgewise Therapeutics. C.S.P.L. has received research support from NovoNordisk and Roche Diagnostics; has received consulting fees from Alleviant Medical, Allysta Pharma, AnaCardio AB, Applied Therapeutics, AstraZeneca, Bayer, Biopeutics, Boehringer Ingelheim, Boston Scientific, Bristol Myers Squibb, CardioRenal, CPC Clinical Research, Eli Lilly, Impulse Dynamics, Intellia Therapeutics, Ionis Pharmaceutical, Janssen Research & Development LLC, Medscape/WebMD Global LLC, Merck, Novartis, Novo Nordisk, Prosciento Inc, Quidel Corporation, Radcliffe Group Ltd., Recardio Inc, ReCor Medical, Roche Diagnostics, Sanofi, Siemens Healthcare Diagnostics, and Us2.ai; and is a co-founder & non-executive director of Us2.ai.

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