Mast Cells Are Intrinsically Primed for Degranulation in DOCK8 Deficiency

Nyssa B Samanas¹, Irina Miralda¹, Nate Camp¹, Josie Sachen¹, Victoria Puryear¹, Liyana Shah¹, Albert J Seo¹, Jake S Foronda¹, Madelyn Shapiro¹, Safa Baris^{2

3

4}, Ekrem Unal^{5

6}, Ahmet Eken^{7

8

9}, Shane D Morrison¹⁰, Eric J Allenspach^{1

11}, Gail H Deutsch¹², Richard G James^{1

11

13}, Adrian M Piliponsky^{1

11

14

15}

Affiliations

¹ Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.
² Division of Pediatric Allergy and Immunology, Marmara University School of Medicine, Istanbul, Turkey.
³ Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Istanbul, Turkey.
⁴ The Isil Barlan Center for Translational Medicine, Istanbul, Turkey.
⁵ Pediatric Hematology and Oncology Clinic, Medical Point Hospital, Gaziantep, Turkey.
⁶ School of Health Sciences, Hasan Kalyoncu University, Gaziantep, Turkey.
⁷ Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
⁸ Department of Medical Biology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
⁹ Genome and Stem Cell Center (GENKOK), Erciyes University, Kayseri, Turkey.
¹⁰ Division of Plastic Surgery, Department of Surgery, Seattle Children's Hospital, Seattle, Washington, USA.
¹¹ Departments of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.
¹² Department of Laboratories, Seattle Children's Research Institute, Seattle, Washington, USA.
¹³ Department of Pharmacology, University of Washington, Seattle, Washington, USA.
¹⁴ Department of Pathology, University of Washington, Seattle, Washington, USA.
¹⁵ Department of Global Health, University of Washington School of Medicine, Seattle, Washington, USA.

Nyssa B Samanas et al. Allergy. 2025 Sep.

. 2025 Sep;80(9):2650-2653.

doi: 10.1111/all.16651. Epub 2025 Jul 14.

¹ Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.
² Division of Pediatric Allergy and Immunology, Marmara University School of Medicine, Istanbul, Turkey.
³ Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Istanbul, Turkey.
⁴ The Isil Barlan Center for Translational Medicine, Istanbul, Turkey.
⁵ Pediatric Hematology and Oncology Clinic, Medical Point Hospital, Gaziantep, Turkey.
⁶ School of Health Sciences, Hasan Kalyoncu University, Gaziantep, Turkey.
⁷ Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
⁸ Department of Medical Biology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
⁹ Genome and Stem Cell Center (GENKOK), Erciyes University, Kayseri, Turkey.
¹⁰ Division of Plastic Surgery, Department of Surgery, Seattle Children's Hospital, Seattle, Washington, USA.
¹¹ Departments of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.
¹² Department of Laboratories, Seattle Children's Research Institute, Seattle, Washington, USA.
¹³ Department of Pharmacology, University of Washington, Seattle, Washington, USA.
¹⁴ Department of Pathology, University of Washington, Seattle, Washington, USA.
¹⁵ Department of Global Health, University of Washington School of Medicine, Seattle, Washington, USA.

No abstract available

Keywords: animal models; basic immunology; immune deficiencies; mast cells.

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