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. 2025 Jan-Feb;16(1):65-80.
doi: 10.32598/bcn.2023.3978.1. Epub 2025 Jan 1.

Effect of Bumetanide on Neural Correlates of Emotion Recognition in Youth With Autism Spectrum Disorder: An Event-related Potential Study

Raheleh Mollajani  1   2 , Mohamad Taghi Joghataei  2   3 , Mehdi Tehrani-Doost  2   4 , Reza Khosrowabadi  2   5
Affiliations

Effect of Bumetanide on Neural Correlates of Emotion Recognition in Youth With Autism Spectrum Disorder: An Event-related Potential Study

Raheleh Mollajani et al. Basic Clin Neurosci. 2025 Jan-Feb.

Abstract

Introduction: Individuals with autism spectrum disorder (ASD) have impairments in emotion processing, including recognizing facial emotions. There is a significant need for medication to improve core symptoms of ASD. Bumetanide is one of the most recently used drugs in some studies of ASD to address this need. This study aimed to evaluate the effect of bumetanide on the brain response of youth with ASD while they were recognizing facial emotions using the event-related potentials (ERPs).

Methods: Fifteen children with ASD aged between 7 to 16 years were evaluated using the childhood autism rating scale (CARS), schedule for affective disorders and schizophrenia for school-age children-present and lifetime version, social responsiveness scale, Wechsler intelligence scale for children-revised form, and standard blood tests. The electrical brain response was measured while they were doing a facial emotion recognition task (FERT). After 3 months of treatment, they were assessed again regarding core symptoms and ERPs.

Results: The behavioral problems of the participants decreased significantly based on CARS. With regard to behavioral performance on FERT, the accuracy of detecting emotions increased, and reaction time decreased significantly. The amplitude of N170, EPN, and N250 increased, and latency for N170 and N250 decreased significantly in some electrodes. There were no serious side effects.

Conclusion: In this study, bumetanide improved behavioral symptoms and recognition of facial emotions. Also, brain function was improved based on the ERP components. So, bumetanide can be used safely in children and adolescents with ASD to improve the main symptoms of the disorder.

Keywords: Autism spectrum disorder (ASD); Bumetanide; Event-related potentials (ERPs); Facial emotion recognition.

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Figures

Figure 1.
Figure 1.
Grand averages of the components for the happy, sad, and neutral expressions A) Grand averages of the ERP components for the happy, sad, and neutral expressions in the pre-test, B) Grand averages of the ERP components for the happy, sad, and neutral expressions in the post-test
Figure 2.
Figure 2.
Event-related potiential scalp distributions of the A. N170, B. EPN, and C. N250 in each facial expression
See this image and copyright information in PMC

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References

    1. Adolphs R., Gosselin F., Buchanan T. W., Tranel D., Schyns P., Damasio A. R. (2005). A mechanism for impaired fear recognition after amygdala damage. Nature, 433(7021), 68–72. [DOI: 10.1038/nature03086] - DOI - PubMed
    1. Akechi H., Senju A., Kikuchi Y., Tojo Y., Osanai H., Hasegawa T. (2010). The effect of gaze direction on the processing of facial expressions in children with autism spectrum disorder: An ERP study. Neuropsychologia, 48(10), 2841–2851. [DOI: 10.1016/j.neuropsychologia.2010.05.026] - DOI - PubMed
    1. American Psychiatric Association (APA) . (2013). Diagnostic and statistical manual of mental disorders: DSM-5TM, 5th ed. Arlington: American Psychiatric Publishing. [DOI: 10.1176/appi.books.9780890425596] - DOI
    1. Apicella F., Sicca F., Federico R. R., Campatelli G., Muratori F. (2013). Fusiform gyrus responses to neutral and emotional faces in children with autism spectrum disorders: A high density ERP study. Behavioural Brain Research, 251, 155–162. [DOI: 10.1016/j.bbr.2012.10.040 - DOI - PubMed
    1. Ashwin C., Chapman E., Colle L., Baron-Cohen S. (2006). Impaired recognition of negative basic emotions in autism: A test of the amygdala theory. Social Neuroscience, 1(3–4), 349–363. [DOI: 10.1080/17470910601040772] - DOI - PubMed

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