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Editorial
. 2025 Jun 27:16:1639004.
doi: 10.3389/fimmu.2025.1639004. eCollection 2025.

Editorial: Community series in targeting signalling pathways in inflammatory diseases, volume II

Mirza S Baig #  1 , Faaiza Siddiqi #  1 , Rajat Atre #  1 , Suraj P Parihar  2 , Syed Faisal  3 , Uzma Saqib  4
Affiliations
Editorial

Editorial: Community series in targeting signalling pathways in inflammatory diseases, volume II

Mirza S Baig et al. Front Immunol. .
No abstract available

Keywords: TIRAP (TIR domain-containing adaptor protein); anti-inflammatory drugs; cytokines; inflammation; macrophages; peptide inhibitors; small-molecule inhibitors.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

Figure 1
Figure 1
(A) Interaction of the TIR domain of TIRAP with various proteins involved in TLR-mediated signaling. (B) Strategies for inhibiting the TIR domain of TIRAP, including small molecules, combination therapies, and peptide-based approaches. (C) Diagrammatic representation showing inhibition of TIR domain interactions between TIRAP and BTK or PKCδ through targeted small molecules, combination treatments, or peptides.
See this image and copyright information in PMC

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  • Editorial on the Research Topic Community series in targeting signalling pathways in inflammatory diseases, volume II

References

    1. Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. (2001) 413:78–83. doi: 10.1038/35092578 - DOI - PubMed
    1. Rajpoot S, Wary KK, Ibbott R, Liu D, Saqib U, Thurston TLM, et al. TIRAP in the mechanism of inflammation. Front Immunol. (2021) 12:697588. doi: 10.3389/fimmu.2021.697588 - DOI - PMC - PubMed
    1. Saqib U, Baig M. Identifying the inhibition of TIR proteins involved in TLR signalling as an anti-inflammatory strategy. SAR QSAR Environ Res. (2018) 29:295–318. doi: 10.1080/1062936X.2018.1431308 - DOI - PubMed
    1. Gay NJ, Gangloff M. Structure and function of toll receptors and their ligands. Annu Rev Biochem. (2007) 76:141–65. doi: 10.1146/annurev.biochem.76.060305.151318 - DOI - PubMed
    1. Nguyen TTN, Kim YM, Kim TD, Le OTT, Kim JJ, Kang HC, et al. Phosphatidylinositol 4-Phosphate 5-Kinase α facilitates toll-like receptor 4-mediated microglial inflammation through regulation of the toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location. J Biol Chem. (2013) 288:5645–59. doi: 10.1074/jbc.M112.410126 - DOI - PMC - PubMed

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