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. 2025 Jun 27:13:1545171.
doi: 10.3389/fpubh.2025.1545171. eCollection 2025.

Human papillomavirus vaccine uptake and associated factors among adolescent girls in Bona district, Sidama regional state, Ethiopia: a community-based study design

Getahun Tiruye  1   2 , Aster Sodo  1 , Abera Kenay Tura  2 , Anteneh Dirar  1   3 , Adera Debella  2 , Kasiye Shiferaw  2
Affiliations

Human papillomavirus vaccine uptake and associated factors among adolescent girls in Bona district, Sidama regional state, Ethiopia: a community-based study design

Getahun Tiruye et al. Front Public Health. .

Abstract

Introduction: In developing nations, adult women's cancer deaths are mostly caused by cervical cancer. Vaccination against the human papillomavirus (HPV) is one of the cost-effective global strategies for cervical cancer prevention, though vaccine uptake remains low in low-resource settings like Ethiopia. Despite the vaccine's proven effectiveness in tackling cervical-related deaths, there is a dearth of evidence in Ethiopia, particularly in the study region, regarding the HPV vaccine uptake and its influencing factors.

Objective: This study aimed to determine HPV vaccination uptake and its associated factors among adolescent girls aged 14-19 years in the Bona district of Sidama regional State of Ethiopia.

Methods: A community-based cross-sectional study was conducted in the Bona district, Sidama region, Ethiopia, from June 1, 2024, to July 29, 2024. A systematic random sampling method was employed to recruit 833 study participants. Data were collected using a pretested, structured interviewer-administered questionnaire. The collected data were entered into Epi Data version 4.6 and exported to SPSS version 25 software for final analysis. Binary logistic regression models were used to identify factors associated with HPV vaccine uptake. Variables with a p-value <0.05 in the multivariable logistic regression were declared statistically significant predictors of HPV uptake.

Results: In this study, the overall prevalence of HPV vaccination uptake was 49.58% [(95% CI: 46.18-52.98)]. Urban residence [AOR = 2.84 (95% CI: 1.87-4.31)], Educational status with college and above [AOR = 1.79 (95% CI 1.23-3.67)], Overall knowledge about HPV infection vaccine and cervical cancer [AOR = 2.53 (1.82-3.51)] and positive attitude towards vaccination [AOR = 2.12 (95% CI: 1.53-2.94)] were significantly associated with HPV vaccine uptake.

Conclusion: Almost one in two girls in the district took the HPV vaccine. The study implies that empowering women through education, promoting health awareness about HPV, cervical cancer, and the HPV vaccine, and implementing targeted interventions for rural populations are essential means to increase HPV vaccine uptake.

Keywords: Bona district; Ethiopia; HPV; adolescent girls; vaccination uptake.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Schematic presentation of sampling procedures for assessment of HPV vaccine uptake and associated factors among adolescent girls aged 14-19 years in Bona district, Sidama region, Ethiopia, 2024 (n=844).
Figure 2
Figure 2
An overall knowledge of adolescent girls aged 14 19 years in Bona distlict, Sidama regional state, Ethiopia, 2024 (n = 833).
Figure 3
Figure 3
Source of information about human papillomavims of adolescent girls aged 14 19 years in Bona district, Sidama regional state, Ethiopia, 2024 (n = 362).
Figure 4
Figure 4
Categories of an overall (cumulative) attitude towards HPV vaccination of adolescent girls aged 14 — 19 years in Bona district, Sidama regional state, Ethiopia, 2024 (n = 833).
See this image and copyright information in PMC

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