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. 2025 Jun;17(Suppl 2):S1908-S1910.
doi: 10.4103/jpbs.jpbs_186_25. Epub 2025 Jun 18.

Evaluation of Antimicrobial Efficacy of Different Irrigants Mixed with Silver Nanoparticles - An In Vivo Study

Ajay Chhabra  1 , Himani Mehra  1 , Priyanka Yadav  1 , K P Ramya  1 , Saravana B Prathap  1 , Mallika Sengupta  2 , Sona J Parvathy  1 , Vandana Chhabra  3
Affiliations

Evaluation of Antimicrobial Efficacy of Different Irrigants Mixed with Silver Nanoparticles - An In Vivo Study

Ajay Chhabra et al. J Pharm Bioallied Sci. 2025 Jun.

Abstract

Aim: To evaluate the antimicrobial efficacy of different irrigants combined with silver nanoparticles.

Materials and methods: Thirty-five patients were divided into seven groups (two control and five experimental), including Group 1: negative control (normal saline), Group 2: positive control (sodium hypochlorite), and Group 3 (sodium hypochlorite + AgNP), Group 4 (Twin Kleen), Group 5 (Twin Kleen + AgNP), Group 6 (Q Mix), and Group 7 (Q Mix + AgNP). Pre- and post-treatment bacterial samples were collected for analysis.

Results: Sodium hypochlorite combined with silver nanoparticles demonstrated the highest antimicrobial efficacy among the tested irrigants, with a significant difference confirmed by the Chi-square statistical analysis.

Conclusion: Within the limitations of the study, it can be concluded that sodium hypochlorite when mixed with the silver nanoparticles showed higher antimicrobial efficacy as compared to the other tested groups.

Keywords: Antimicrobial efficacy; Q Mix; Twin Kleen; root canal irrigants; silver nanoparticles; sodium hypochlorite.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Colony-forming units grown on blood agar
See this image and copyright information in PMC

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