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. 2025 Jun 12;17(6):e85843.
doi: 10.7759/cureus.85843. eCollection 2025 Jun.

Oral Rehabilitation and Mental Health: Effects of the Renew Procedure on Depression Scores

Austin F Cross  1 , William L Balanoff  1 , Bernard Schayes  2   3 , William Jayne  1
Affiliations

Oral Rehabilitation and Mental Health: Effects of the Renew Procedure on Depression Scores

Austin F Cross et al. Cureus. .

Abstract

The Renew Procedure is an elective comprehensive surgical and prosthetic intervention designed to address severe oral health issues, particularly periodontitis, and by systematically eliminating sources of chronic inflammation in the mouth, overall systemic health may improve. Additionally, restoring functionality and aesthetics to the mouth can significantly enhance a patient's quality of life. This study investigates whether improvements in oral health via the Renew Procedure correlate with measurable reductions in depressive symptoms, as assessed using the Patient Health Questionnaire-9 (PHQ-9), a pre- and post-operative assessment administered to patients undergoing full-mouth rehabilitation with the Renew Procedure. The results indicate a statistically significant decrease in PHQ-9 scores, suggesting that the intervention may contribute to improved mental health outcomes. These findings support the need for integrated healthcare approaches that recognize the interconnections between oral health, systemic inflammation, and mental well-being.

Keywords: depression; implant-retained dentures; inflammation; mental health; oral-systemic connection; patient health questionnaire-9 (phq-9); periodontitis; social determinants of health (sdoh); systemic health.

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Conflict of interest statement

Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Sterling Institutional Review Board (IRB) issued approval 11273-WBalanoff. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Intellectual property info: Serial No: 18/900,443; Filing Date: September 27, 2024; Inventors: William L. Balanoff, Austin F. Cross, and Bernard Schayes; Applicant: Renew LLC, Centennial, Colorado; Patent Application: Method for Reducing Hemoglobin A1C Levels and Improving Other Medical Conditions for a Patient Diagnosed With Type II Diabetes; File No:. 1712.8024. Other relationships: All authors are affiliated with Renew LLC through employment, both past and present.

Figures

Figure 1
Figure 1. Patient Health Questionnaire-9 (PHQ-9)
Created by the authors
See this image and copyright information in PMC

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