Extensive Cerebral Venous Sinus Thrombosis at High Altitude
- PMID: 40656429
- PMCID: PMC12246765
- DOI: 10.7759/cureus.85742
Extensive Cerebral Venous Sinus Thrombosis at High Altitude
Abstract
Rapid ascent to altitudes above 8,000 feet (2,500 meters) is known to be associated with acute mountain sickness (AMS), but its role as a cause of cerebrovascular disorders is rarely described. Cerebral venous sinus thrombosis is a rare and potentially fatal condition that can frequently be misdiagnosed. In this article, we report an unusual case of a 27-year-old woman who developed an extensive cerebral venous sinus thrombosis (CVST) during an expedition in the Atlas Mountains. The underlying mechanisms explaining this event will be discussed in light of this clinical observation.
Keywords: acute mountain sickness; anticoagulation; cerebral edema; cerebral venous sinus thrombosis; cerebrovascular disease; high altitude; magnetic resonance imaging (mri).
Copyright © 2025, Ouachaou et al.
Conflict of interest statement
Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
Figures
Similar articles
-
Interventions for treating acute high altitude illness.Cochrane Database Syst Rev. 2018 Jun 30;6(6):CD009567. doi: 10.1002/14651858.CD009567.pub2. Cochrane Database Syst Rev. 2018. PMID: 29959871 Free PMC article.
-
Interventions for preventing high altitude illness: Part 2. Less commonly-used drugs.Cochrane Database Syst Rev. 2018 Mar 12;3(3):CD012983. doi: 10.1002/14651858.CD012983. Cochrane Database Syst Rev. 2018. PMID: 29529715 Free PMC article.
-
Interventions for preventing high altitude illness: Part 1. Commonly-used classes of drugs.Cochrane Database Syst Rev. 2017 Jun 27;6(6):CD009761. doi: 10.1002/14651858.CD009761.pub2. Cochrane Database Syst Rev. 2017. PMID: 28653390 Free PMC article.
-
Safety and efficacy of endovascular thrombolysis in patients with acute cerebral venous sinus thrombosis: A systematic review.Interv Neuroradiol. 2024 Oct;30(5):746-758. doi: 10.1177/15910199221143418. Epub 2022 Dec 5. Interv Neuroradiol. 2024. PMID: 36471504 Free PMC article.
-
Ventilator Management(Archived).2023 Mar 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2023 Mar 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 28846232 Free Books & Documents.
References
-
- Cerebral venous thrombosis: an update. Bousser MG, Ferro JM. Lancet Neurol. 2007;6:162–170. - PubMed
-
- Thrombosis of the cerebral veins and sinuses. Stam J. N Engl J Med. 2005;352:1791–1798. - PubMed
-
- European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis - endorsed by the European Academy of Neurology. Ferro JM, Bousser MG, Canhão P, et al. Eur J Neurol. 2017;24:1203–1213. - PubMed
-
- Physiology and pathophysiology with ascent to altitude. Palmer BF. Am J Med Sci. 2010;340:69–77. - PubMed
-
- Humans at altitude: physiology and pathophysiology. Brown JP, Grocott MP. https://doi.org/10.1093/bjaceaccp/mks047 Cont Educ Anaesth Crit Care Pain. 2013;13:17–22.
Publication types
LinkOut - more resources
Full Text Sources