Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2025 Jun 26;7(2):214-219.
doi: 10.36519/idcm.2025.501. eCollection 2025 Jun.

Diagnostically Challenging Case: Coexistence of Two Zoonoses

Melike Törüyenler-Coşkunpınar  1 , İrem Akdemir  1 , Seher Yüksel  2 , Nermin Aras  2 , Meltem Kurt-Yüksel  3 , Alpay Azap  1
Affiliations
Case Reports

Diagnostically Challenging Case: Coexistence of Two Zoonoses

Melike Törüyenler-Coşkunpınar et al. Infect Dis Clin Microbiol. .

Abstract

A male patient presented with fever, cytopenia, and hepatosplenomegaly. The patient's Brucella tube agglutination test was positive at titers 1:640. Due to the lack of response to brucellosis treatment, additional tests were performed. Leishmania amastigotes were seen in the second bone marrow biopsy preparations. Leishmania PCR was positive, and visceral leishmaniasis (VL) was diagnosed. Here, we present a case of VL and brucellosis coinfection that presented with B symptoms (fever, night sweats, and weight loss) and cytopenia and was difficult to diagnose.

Keywords: brucellosis; coinfection; Visceral leishmaniasis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Leishmania bodies are seen in macrophages in the bone marrow aspiration smear.
Figure 2
Figure 2
C-reactive protein and body temperature values monitored during the patient’s hospitalization.
See this image and copyright information in PMC

References

    1. World Health Organization Leishmaniasis. Geneva: World Health Organization; 2023 Jan 12. [May 16, 2024]. https://www.who.int/news-room/fact-sheets/detail/leishmaniasis
    1. Burza S, Croft SL, Boelaert M. Leishmaniasis. Lancet. 2018;392(10151):951–970. doi: 10.1016/S0140-6736(18)31204-2. - DOI - PubMed
    1. Mann S, Frasca K, Scherrer S, Henao-Martínez AF, Newman S, Ramanan P, et al. A review of Leishmaniasis: current knowledge and future directions. Curr Trop Med Rep. 2021;8(2):121–132. doi: 10.1007/s40475-021-00232-7. - DOI - PMC - PubMed
    1. Magill AJ. In: Mandell, Douglas, and Bennett’s principles and practice of infectious diseases. 9th ed. Bennett JE, Dolin R, Blaser MJ, editors. Elsevier; Philadelphia: 2020. Leishmania species: visceral (kala-azar), cutaneous, and mucosal leishmaniasis; pp. 3091–3107.
    1. Özbel Y, Töz S, Muñoz C, Ortuño M, Jumakanova Z, Pérez-Cutillas P, et al. The current epidemiology of leishmaniasis in Turkey, Azerbaijan and Georgia and implications for disease emergence in European countries. Zoonoses Public Health. 2022;69(5):395–407. doi: 10.1111/zph.12977. - DOI - PMC - PubMed

Publication types

LinkOut - more resources