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Review
. 2025 Jul 15;39(7):903-911.
doi: 10.7507/1002-1892.202504117.

[Effect of mechanical stimuli on physicochemical properties of joint fluid in osteoarthritis]

[Article in Chinese]
Han Yao  1   2   3 , Aixian Tian  1   2   3 , Jianxiong Ma  1   2   3 , Xinlong Ma  1   2   3
Affiliations
Review

[Effect of mechanical stimuli on physicochemical properties of joint fluid in osteoarthritis]

[Article in Chinese]
Han Yao et al. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. .

Abstract
in English, Chinese

Objective: To analyze the differences in the effects of different mechanical stimuli on cells, cytokines, and proteins in synovial fluid of osteoarthritis joints, and to elucidate the indirect mechanism by which mechanical signals remodel the synovial fluid microenvironment through tissue cells.

Methods: Systematically integrate recent literature, focusing on the regulatory effects of different mechanical stimuli on the physicochemical properties of synovial fluid. Analyze the dynamic process by which mechanical stimuli regulate secretory and metabolic activities through tissue cells, thereby altering the physicochemical properties of cytokines and proteins.

Results: Appropriate mechanical stimuli activate mechanical signals in chondrocytes, macrophages, and synovial cells, thereby influencing cellular metabolic activities, including inhibiting the release of pro-inflammatory factors and promoting the secretion of anti-inflammatory factors, and regulating the expression of matrix and inflammation-related proteins such as cartilage oligomeric matrix protein, peptidoglycan recognition protein 4, and matrix metalloproteinases.

Conclusion: Mechanical stimuli act on tissue cells, indirectly reshaping the synovial fluid microenvironment through metabolic activities, thereby regulating the pathological process of osteoarthritis.

目的: 分析不同力学刺激对骨关节炎关节液中细胞、细胞因子及蛋白质的作用差异，阐述力学信号通过组织细胞介导重塑关节液微环境的间接机制。.

方法: 系统整合近年文献，聚焦不同力学刺激对关节液理化性质的调控结果，分析力学刺激通过组织细胞调控分泌与代谢活动，改变细胞因子与蛋白质理化性质的动态过程。.

结果: 适宜力学刺激通过激活软骨细胞、巨噬细胞、滑膜细胞的力学信号，从而影响细胞的代谢活动，包括抑制促炎因子的释放并促进抗炎因子的分泌，调节基质和炎症相关蛋白软骨寡聚基质蛋白、肽聚糖识别蛋白 4和基质金属蛋白酶的表达。.

结论: 力学刺激通过作用于组织细胞，经代谢活动间接重塑关节液微环境，进而调控骨关节炎病理进程。.

Keywords: Osteoarthritis; cartilage; mechanical stimulation; synovial fluid.

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Conflict of interest statement

利益冲突 在课题研究和文章撰写过程中不存在利益冲突；经费支持没有影响文章观点及其报道

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