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. 2025 Jul 14;8(1):438.
doi: 10.1038/s41746-025-01844-3.

Physical activity and diet just-in-time adaptive intervention to reduce blood pressure: a randomized controlled trial

Michael P Dorsch #  1 , Jessica R Golbus #  2   3 , Rachel Stevens  2 , Brad Trumpower  2 , Tanima Basu  2 , Evan Luff  2 , Kimberly Warden  4 , Michael Giacalone  4 , Sarah Bailey  5 , Gabriella V Rubick  2 , Sonali Mishra  2 , Predrag Klasnja  6 , Mark W Newman  6 , Lesli E Skolarus  7 , Brahmajee K Nallamothu  2   3   8
Affiliations

Physical activity and diet just-in-time adaptive intervention to reduce blood pressure: a randomized controlled trial

Michael P Dorsch et al. NPJ Digit Med. .

Abstract

Mobile health interventions for behavioral change require large-scale studies to ensure their clinical benefits. We conducted a randomized controlled trial of patients with hypertension to assess the myBPmyLife application in promoting physical activity and lower-sodium foods to lower systolic blood pressure (SBP). 602 participants were randomly assigned to either a control group or an intervention group that received the myBPmyLife application. For the primary outcome, change in SBP over 6 months was -5.2 mmHg in the intervention and -5.7 mmHg in the control group (p = 0.76). For secondary outcomes, the intervention group increased their daily step count by 170 steps, while the control group decreased by 319 steps (p = 0.040). Sodium intake decreased by 1145 mg in the intervention and 860 mg in the control group (p = 0.002). The myBPmyLife application did not reduce SBP over 6 months in hypertension patients despite increasing step counts and lowering sodium intake. ClinicalTrials.gov registration: NCT05154929, 12/2021.

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Consort diagram.
The progress through the phases of the randomized trial.
Fig. 2
Fig. 2. Blood pressure between the intervention and control groups.
The change of systolic and diastolic blood pressure from baseline to 6 months. The data are presented in mean +/− standard error of the mean.
Fig. 3
Fig. 3. Mean daily step count between the intervention and control groups.
The change in mean daily step count from baseline to 6 months. The data are presented in mean +/- standard error of the mean.
Fig. 4
Fig. 4. Estimated dietary sodium intake between the intervention and control groups.
The change in dietary sodium intake from baseline to 6 months. The data are presented in mean +/- standard error of the mean.
See this image and copyright information in PMC

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