Placenta - A Competent, But Not Infallible, Antiviral and Antiparasitic Barrier

doi:10.1007/s43032-025-01921-8

Review

. 2025 Jul 14.

doi: 10.1007/s43032-025-01921-8. Online ahead of print.

Placenta - A Competent, But Not Infallible, Antiviral and Antiparasitic Barrier

Christian Castillo^#¹, Helena Hae Jin Chi^#², Larissa Bornia Ghilardi², Ana Liempi¹, Maria Notomi Sato³, Ulrike Kemmerling⁴, Estela Bevilacqua⁵

Affiliations

¹ Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
² Laboratory for Studies on Maternal-Fetal Interactions and Placenta, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, SP, Brazil.
³ Laboratory of Dermatology and Immunodeficiencies, Department of Dermatology, School of Medicine, Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, Brazil.
⁴ Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile. ukemmerling@uchile.cl.
⁵ Laboratory for Studies on Maternal-Fetal Interactions and Placenta, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, SP, Brazil. bevilacq@usp.br.

^# Contributed equally.

PMID: 40660015
DOI: 10.1007/s43032-025-01921-8

Review

Placenta - A Competent, But Not Infallible, Antiviral and Antiparasitic Barrier

Christian Castillo et al. Reprod Sci. 2025.

. 2025 Jul 14.

doi: 10.1007/s43032-025-01921-8. Online ahead of print.

Authors

Christian Castillo^#¹, Helena Hae Jin Chi^#², Larissa Bornia Ghilardi², Ana Liempi¹, Maria Notomi Sato³, Ulrike Kemmerling⁴, Estela Bevilacqua⁵

Affiliations

¹ Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
² Laboratory for Studies on Maternal-Fetal Interactions and Placenta, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, SP, Brazil.
³ Laboratory of Dermatology and Immunodeficiencies, Department of Dermatology, School of Medicine, Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, Brazil.
⁴ Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile. ukemmerling@uchile.cl.
⁵ Laboratory for Studies on Maternal-Fetal Interactions and Placenta, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, SP, Brazil. bevilacq@usp.br.

^# Contributed equally.

PMID: 40660015
DOI: 10.1007/s43032-025-01921-8

No abstract available

Keywords: Innate immunity; Parasite infection; Placenta; Vertical transmission; Viral infection.

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Conflict of interest statement

Declarations. Conflict of Interest: The authors declare that the research was conducted without any commercial or financial relationships that could be considered potential conflicts of interest.

References

1. Baergen RN, Burton GJ, Kaplan CG, editors. Benirschke’s pathology of the human placenta. Cham: Springer International Publishing; 2022. https://doi.org/10.1007/978-3-030-84725-8 . - DOI
1. Pijnenborg R, Dixon G, Robertson WB, Brosens I. Trophoblastic invasion of human decidua from 8 to 18 weeks of pregnancy. Placenta. 1980;1:3–19. https://doi.org/10.1016/s0143-4004(80)80012-9 . - DOI - PubMed
1. Norwitz ER, Schust DJ, Fisher SJ. Implantation and the survival of early pregnancy. N Engl J Med. 2001;345:1400–8. https://doi.org/10.1056/NEJMra000763 . - DOI - PubMed
1. Burton GJ, Fowden AL. The placenta: a multifaceted, transient organ. Philos Trans R Soc B Biol Sci. 2015;370:20140066. https://doi.org/10.1098/rstb.2014.0066 . - DOI
1. Pereira L. Congenital viral infection: traversing the uterine-placental interface. Annu Rev Virol. 2018;5:273–99. https://doi.org/10.1146/annurev-virology-092917-043236 . - DOI - PubMed

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[1] Baergen RN, Burton GJ, Kaplan CG, editors. Benirschke’s pathology of the human placenta. Cham: Springer International Publishing; 2022. https://doi.org/10.1007/978-3-030-84725-8 . - DOI

[2] Baergen RN, Burton GJ, Kaplan CG, editors. Benirschke’s pathology of the human placenta. Cham: Springer International Publishing; 2022. https://doi.org/10.1007/978-3-030-84725-8 . - DOI

[3] Pijnenborg R, Dixon G, Robertson WB, Brosens I. Trophoblastic invasion of human decidua from 8 to 18 weeks of pregnancy. Placenta. 1980;1:3–19. https://doi.org/10.1016/s0143-4004(80)80012-9 . - DOI - PubMed

[4] Pijnenborg R, Dixon G, Robertson WB, Brosens I. Trophoblastic invasion of human decidua from 8 to 18 weeks of pregnancy. Placenta. 1980;1:3–19. https://doi.org/10.1016/s0143-4004(80)80012-9 . - DOI - PubMed

[5] Norwitz ER, Schust DJ, Fisher SJ. Implantation and the survival of early pregnancy. N Engl J Med. 2001;345:1400–8. https://doi.org/10.1056/NEJMra000763 . - DOI - PubMed

[6] Norwitz ER, Schust DJ, Fisher SJ. Implantation and the survival of early pregnancy. N Engl J Med. 2001;345:1400–8. https://doi.org/10.1056/NEJMra000763 . - DOI - PubMed

[7] Burton GJ, Fowden AL. The placenta: a multifaceted, transient organ. Philos Trans R Soc B Biol Sci. 2015;370:20140066. https://doi.org/10.1098/rstb.2014.0066 . - DOI

[8] Burton GJ, Fowden AL. The placenta: a multifaceted, transient organ. Philos Trans R Soc B Biol Sci. 2015;370:20140066. https://doi.org/10.1098/rstb.2014.0066 . - DOI

[9] Pereira L. Congenital viral infection: traversing the uterine-placental interface. Annu Rev Virol. 2018;5:273–99. https://doi.org/10.1146/annurev-virology-092917-043236 . - DOI - PubMed

[10] Pereira L. Congenital viral infection: traversing the uterine-placental interface. Annu Rev Virol. 2018;5:273–99. https://doi.org/10.1146/annurev-virology-092917-043236 . - DOI - PubMed

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Placenta - A Competent, But Not Infallible, Antiviral and Antiparasitic Barrier

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Placenta - A Competent, But Not Infallible, Antiviral and Antiparasitic Barrier

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