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Randomized Controlled Trial
. 2025 Jul 11;104(28):e43373.
doi: 10.1097/MD.0000000000043373.

An observational study of the efficacy of combined orthodontic-systemic periodontal treatment

Shiwei Miao  1 , Yinghong Wu, Hong Ning, Junjie Xu
Affiliations
Randomized Controlled Trial

An observational study of the efficacy of combined orthodontic-systemic periodontal treatment

Shiwei Miao et al. Medicine (Baltimore). .

Abstract

This study comparatively analyzes the periodontal status of patients at 6 months after combined orthodontic-systemic periodontal treatment for improving clinical treatment protocols. Eighty periodontitis patients treated in our hospital from June 2019 to June 2022 were selected as subjects and randomly divided into observation and control groups, with 40 patients in each group. The observation group underwent combined orthodontic-systemic periodontal treatment; the control group underwent systemic periodontal treatment. All subjects had been followed up for 6 months, they underwent periodontal clinical examination and gingival crevicular fluid detection at 6 months after treatment; the effective rate was compared between 2 groups. The total effective rate was higher in the observation group (97.50%) than in the control group (87.50%). Compared with before treatment, the clinical attachment loss, gingival bleeding index, periodontal probing depth, plaque index, bleeding on probing, tumor necrosis factor-α, interleukin-6, and interleukin-1β levels in gingival sulcus fluid were significantly decreased in 2 groups at 6 months after treatment, which were lower in the observation group than in the control group, with statistically significant differences (P < .05). Combined orthodontic-systemic periodontal treatment can increase the therapeutic effect, improve periodontal status and enhance anti-inflammatory response in periodontitis patients, thus promoting their recovery.

Keywords: interleukin-1β; interleukin-6; orthodontics; periodontitis; systemic periodontal treatment; tumor necrosis factor-α.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Comparison of the total clinical effective rate between the observation group and the control group. The observation group demonstrated a significantly higher effective rate compared to the control group (P < .05).
Figure 2.
Figure 2.
Visual analog scale (VAS) pain scores of the observation group and control group at different time points. There was no significant difference in pain scores before surgery and 3 months postsurgery. However, at 6 months postsurgery, the observation group showed significantly lower pain scores compared to the control group (P < .05).
Figure 3.
Figure 3.
Changes in gingival bleeding index (GBI) before and 6 months after treatment in the observation and control groups. Both groups exhibited significant improvement, with the observation group showing significantly better outcomes than the control group (P < .01).
Figure 4.
Figure 4.
Changes in periodontal probing depth (PPD) before and 6 months after treatment in the observation and control groups. Both groups showed significant reductions in PPD, with greater improvement observed in the observation group (P < .05).
See this image and copyright information in PMC

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