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Observational Study
. 2025 Jul 11;104(28):e43207.
doi: 10.1097/MD.0000000000043207.

Characteristics of oocyte fertilization and early embryo development in infertile women with different ovarian reserves in the Changde region, China

Donghong Li  1 , Lin Lei  1 , Lei Liu  1 , Yunhao Wang  1 , Chao Yang  1 , Weijing Wang  1 , Bingru Luo  2
Affiliations
Observational Study

Characteristics of oocyte fertilization and early embryo development in infertile women with different ovarian reserves in the Changde region, China

Donghong Li et al. Medicine (Baltimore). .

Abstract

This study investigates the correlation between different ovarian reserves and the oocyte fertilization rate as well as early embryo development in the Changde area. A total of 325 infertile women who underwent in vitro fertilization procedure were recruited in the study and classified according to their anti-Müllerian hormone level into 3 groups: low ovarian reserve (LOR), normal ovarian reserve (NOR), and high ovarian reserve (HOR). Compared with LOR, the rate of total fertilization, the number of oocytes retrieved, day 3 good quality embryo and blastocyst formation were found to be significantly increased in NOR and HOR, respectively. These indicators were not significantly different between NOR and HOR. In the Changde area, the serum E2 levels and the number of follicles larger than 14 mm in infertile women on the trigger day significantly increased with higher ovarian reserve, but the ratio of E2 to the number of follicles larger than 14 mm was found to be unrelated to ovarian reserve. A LOR function was observed to reduce the fertilization rate of oocytes, while the early development of embryos was independent of the level of ovarian reserve.

Keywords: early embryonic development; fertilization; in vitro fertilization; ovarian reserve; serum estradiol level.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Distribution of the natural logarithm of serum AMH levels versus age. The natural logarithm of serum AMH levels for all patients was plotted along the y-axis, while their ages were represented on the x-axis. AMH = anti-Müllerian hormone.
Figure 2.
Figure 2.
Distribution of serum AMH levels across different age groups. The serum AMH levels of all patients were plotted on the y-axis, with age represented on the x-axis. The data revealed a gradual decline in serum AMH levels as age increased, and AMH levels were significantly lower in individuals aged 45 and older compared to other age groups. AMH = anti-Müllerian hormone.
See this image and copyright information in PMC

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