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[Preprint]. 2025 Jun 15:2025.06.10.658978.
doi: 10.1101/2025.06.10.658978.

Effects of Ambient Temperature During Pregnancy on Newborn Birthweight

Reshma Nargund  1 , Joddy Marchesoni  2 , Akshay Bareja  3   4 , David W Sosnowski  5 , Gang Peng  6 , Cathrine Hoyo  2 , William Pan  1 , Susan K Murphy  7
Affiliations

Effects of Ambient Temperature During Pregnancy on Newborn Birthweight

Reshma Nargund et al. bioRxiv. .

Abstract

This study evaluates the association between ambient temperature exposure during pregnancy and newborn birthweight, using a penalized generalized additive model (GAM) framework with distributed lag non-linear models (DLNM) to identify sensitive windows of exposure. The analysis includes 238 participants from the SHIP study with complete temperature exposure and birthweight data. Weekly maximum temperatures during pregnancy were estimated using Daymet data, and the impact of temperature on birthweight was assessed, adjusting for maternal age, pre-pregnancy BMI, gestational age, race, smoking, diabetes status, and infant biological sex. The model incorporated a crossbasis function for temperature exposure across 42 gestational weeks and allowed penalization for smoother, data-driven lag estimation. Results from the combined-sex model indicated that higher ambient temperatures during the third trimester, particularly in the final weeks of pregnancy, were associated with increased birthweight. Stratified analyses suggested that this association was more pronounced in male infants. These findings highlight the importance of considering prenatal temperature exposures and timing when evaluating determinants of newborn health.

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Figures

Figure 1:
Figure 1:
Weekly Gestational Temperature Effects on Birthweight - Biological Sexes Combined
Figure 2:
Figure 2:
Weekly Gestational Temperature Effects on Birthweight - Male
Figure 3:
Figure 3:
Weekly Gestational Temperature Effects on Birthweight - Female
Figure 4:
Figure 4:
Weekly Gestational Temperature Effects on Birthweight - Non-Diabetic Mothers
Figure 5:
Figure 5:
Weekly Gestational Temperature Effects on Birthweight - Diabetic Mothers
Figure 6:
Figure 6:
Weekly Gestational Temperature Effects on Birthweight - Average for Gestational Age
Figure 7:
Figure 7:
Weekly Gestational Temperature Effects on Birthweight - Average for Gestational Age - Male
Figure 8:
Figure 8:
Weekly Gestational Temperature Effects on Birthweight - Average for Gestational Age - Female
Figure 9:
Figure 9:
Weekly Gestational Temperature Effects on Birthweight - Small for Gestational Age
Figure 10:
Figure 10:
Weekly Gestational Temperature Effects on Birthweight - Large for Gestational Age
See this image and copyright information in PMC

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