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Review
. 2025 Jul 13;13(7):e70608.
doi: 10.1002/fsn3.70608. eCollection 2025 Jul.

A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy

Muhammad Maaz  1 , Muhammad Tauseef Sultan  1 , Muhammad Usman Khalid  1 , Hassan Raza  1 , Muhammad Imran  2 , Muzzamal Hussain  3 , Waleed Al Abdulmonem  4 , Suliman A Alsagaby  5 , Mohamed A Abdelgawad  6 , Mohammed M Ghoneim  7 , Muhammad Asif Khan  8 , Tadesse Fenta Yehuala  9 , Samy Selim  10 , Ehab M Mostafa  11   12
Affiliations
Review

A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy

Muhammad Maaz et al. Food Sci Nutr. .

Abstract

The continuous progression of cancerous severity due to the interaction of physical (ultraviolet radiation), chemical (smoking, mycotoxins, and heavy metals), and biological (microbial populations) carcinogens inspired scientists to develop a correlation between active therapeutic agents and cancer proliferation. This review highlights the molecular mechanism by which lycopene imparts its anticancerous role, focusing on clinical and animal trials to validate its effectiveness. The antioxidant profile of lycopene promotes anticancerous properties that reduce cancer prevalence by activating cell signaling pathways and gene expression (involved in cancer cell proliferation). Lycopene's anti-inflammatory properties suppresses the tumor growth and development-promoting pathways, such as the PI3K/Akt/mTOR pathway. The anticancer property of lycopene is also evidenced by its inhibitory potential of the Wnt/β-catenin signaling pathway that is involved in cancer cell modulation and propagation. Lycopene also suppresses and neutralizes oxidative stress and reactive oxygen species (ROS)-induced DNA damage, preventing gene mutation. Inflammation-induced cell death is mitigated by lycopene's anti-inflammatory potential that lowers the expression of interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Several clinical and randomized control trials have revealed the effect of lycopene supplementation in the management of cancer, including breast cancer, pancreatic cancer, prostate cancer, colon cancer, ovarian cancer, skin cancer, oral cancer, liver cancer, gastric cancer, and kidney cancer, by lessening prostate-specific antigen (PSA) levels. These studies also accentuate certain limitations that need further trials to evaluate the long-term consequences of lycopene supplementations and their specific effective dose.

Keywords: DNA damage; PSA levels; anticancer; antioxidants; anti‐inflammatory; cancer cell modulation; lycopene; oxidative stress.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Carotenoid bioavailability & dietary factors affecting absorption.
FIGURE 2
FIGURE 2
Anticancerous properties of lycopene.
FIGURE 3
FIGURE 3
Breast cancer preventive mechanism of lycopene.
FIGURE 4
FIGURE 4
Lycopene mechanism of action for lung cancer prevention.
See this image and copyright information in PMC

References

    1. Abir, M. H. , Mahamud A. S. U., Tonny S. H., et al. 2023. “Pharmacological Potentials of Lycopene Against Aging and Aging‐Related Disorders: A Review.” Food Science & Nutrition 11, no. 10: 5701–5735. - PMC - PubMed
    1. Adetunji, C. O. , Akram M., Mtewa A. G., et al. 2021. “Biochemical and Pharmacotherapeutic Potentials of Lycopene in Drug Discovery.” In Preparation of Phytopharmaceuticals for the Management of Disorders, 307–360. Academic Press.
    1. Ağagündüz, D. , Şahin T. Ö., Yılmaz B., Ekenci K. D., Duyar Özer Ş., and Capasso R.. 2022. “Cruciferous Vegetables and Their Bioactive Metabolites: From Prevention to Novel Therapies of Colorectal Cancer.” Evidence‐based Complementary and Alternative Medicine 2022, no. 1: 1534083. - PMC - PubMed
    1. Agah, S. , Akbari A., Sadeghi E., et al. 2021. “Resveratrol Supplementation and Acute Pancreatitis: A Comprehensive Review.” Biomedicine & Pharmacotherapy 137: 111268. - PubMed
    1. Aktepe, O. H. , Şahin T. K., Güner G., Arik Z., and Yalçin Ş.. 2021. “Lycopene Sensitizes the Cervical Cancer Cells to Cisplatin via Targeting Nuclear factorkappaB (NF‐B) Pathway.” Turkish Journal of Medical Sciences 51, no. 1: 368–374. - PMC - PubMed

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