doi: 10.1007/BF00426702.
Increase in mouse brain dopamine content by baclofen: effects of apomorphine and neuroleptics
- PMID: 406622
- DOI: 10.1007/BF00426702
Item in Clipboard
Increase in mouse brain dopamine content by baclofen: effects of apomorphine and neuroleptics
Psychopharmacology (Berl).
.
Abstract
Baclofen, like gamma-butyrolactone, causes a dose-dependent increase in the concentration of dopamine in the mouse brain without affecting the content of norepinephrine. This increase is antagonized by apomorphine. Haloperidol but not pimozide counteracts this effect of apomorphine and dose-dependently enhances the increase in brain dopamine produced by baclofen. The results suggest that baclofen reduces impulse flow in dopaminergic neurons in a manner similar to that produced by gamma-butyrolactone.
Similar articles
-
Differential actions of dopamine agonists and antagonists on the gamma-butyrolactone-induced in mouse brain dopamine.Psychopharmacology (Berl). 1976 Nov 24;50(3):225-9. doi: 10.1007/BF00426836. Psychopharmacology (Berl). 1976. PMID: 826966
-
Delayed inhibition of dopamine synthesis by gamma-butyrolactone and baclofen: dopamine autoreceptor supersensitivity?Eur J Pharmacol. 1982 Nov 5;85(1):23-7. doi: 10.1016/0014-2999(82)90420-4. Eur J Pharmacol. 1982. PMID: 6818043
-
Effects of aminooxyacetic acid and baclofen on the catalepsy and on the increase of mesolimbic and striatal dopamine turnover induced by haloperidol in rats.Acta Pharmacol Toxicol (Copenh). 1976 Sep;39(3):393-400. doi: 10.1111/j.1600-0773.1976.tb03190.x. Acta Pharmacol Toxicol (Copenh). 1976. PMID: 989685 No abstract available.
-
Neuroleptic-induced emotional defecation: effects of pimozide and apomorphine.Physiol Behav. 1989 Aug;46(2):199-202. doi: 10.1016/0031-9384(89)90256-4. Physiol Behav. 1989. PMID: 2602459
-
Behavioural supersensitivity to apomorphine following cerebral dopaminergic denervation by 6-hydroxydopamine.Psychopharmacologia. 1975 May 28;42(2):159-62. doi: 10.1007/BF00429547. Psychopharmacologia. 1975. PMID: 1172249
Cited by
-
The role of monoamines for the central effects of Baclofen on behavior of rats.J Neural Transm. 1979;46(3):215-23. doi: 10.1007/BF01250787. J Neural Transm. 1979. PMID: 528996
-
Effects of intranigral administration of dopamine agonists and antagonists and baclofen on concentrations of dopac and dopamine in the striatum and substantia nigra of the rat.J Neural Transm. 1979;45(2):117-27. doi: 10.1007/BF01250087. J Neural Transm. 1979. PMID: 469523
-
Differential behavioral and biochemical effects of four dopaminergic agonists.Psychopharmacology (Berl). 1980;68(2):139-46. doi: 10.1007/BF00432131. Psychopharmacology (Berl). 1980. PMID: 6107946
-
Effects of baclofen on dopamine-dependent behaviors in mice.Psychopharmacology (Berl). 1981;75(4):396-9. doi: 10.1007/BF00435861. Psychopharmacology (Berl). 1981. PMID: 6803287
-
The effect of baclofen on alpha-flupenthixol-induced catalepsy in the rat.Br J Pharmacol. 1978 Feb;62(2):303-5. doi: 10.1111/j.1476-5381.1978.tb08460.x. Br J Pharmacol. 1978. PMID: 564220 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
