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Meta-Analysis
. 2025 Jul 15;42(5):41.
doi: 10.1007/s10585-025-10361-2.

The prognostic significance of histopathological growth patterns in liver metastases undergoing surgery: a systematic review and meta-analysis

Xiang-Yu Wang #  1 , Bo Zhang #  1 , Yin-Chen Gu #  1 , Mei Yang  2 , Bao-Rui Tao  1 , Rong-Quan Sun  1 , Yi-Tong Li  1 , Zhen-Mei Chen  1 , Sen-Feng Ying  1 , Chen-He Yi  1 , Yan Geng  1 , Rui Zhang  1 , Jie Fan  3 , Jin-Hong Chen  4
Affiliations
Meta-Analysis

The prognostic significance of histopathological growth patterns in liver metastases undergoing surgery: a systematic review and meta-analysis

Xiang-Yu Wang et al. Clin Exp Metastasis. .

Abstract

Histopathological growth pattern (HGP) is emerging as a promising pathological biomarker in liver metastases, with potential associations to prognosis and response to antiangiogenic therapy. Nonetheless, its prognostic role requires further elucidation for substantial heterogeneity of previous studies. We searched PubMed, Web of Science, Embase and Cochrane Library for studies comparing the overall survival (OS) or disease-free survival (DFS) between different HGPs in liver metastases from various cancer types. Data were pooled using hazard ratios (HRs) along with 95% confidence intervals (CIs) according to fixed or random-effects models. Subgroup analysis was also performed to adjust critical confounders. In total, 36 studies were included in the final analysis. It was demonstrated that desmoplastic HGP (dHGP) was associated with favorable OS compared with non-dHGP (HR, 0.59; 95% CI 0.54-0.64), replacement HGP (rHGP, HR, 0.60; 95% CI 0.49-0.74) and pushing HGP (pHGP, HR, 0.63; 95% CI 0.43-0.92), respectively. Similarly, dHGP also demonstrated improved DFS compared with non-dHGP (HR, 0.58; 95% CI 0.52-0.65), rHGP (HR, 0.61; 95% CI 0.49-0.77) and pHGP (HR, 0.51; 95% CI 0.31-0.83), respectively. In subgroup analysis, dHGPs remains an independent prognostic factor regardless of critical confounders, such as the preoperative systemic therapy, cancer types and HGP categorization criteria. This study confirmed the prognostic role of HGPs in liver metastases receiving surgical resection. Clinically, adding HGPs in prognostic models may provide further optimization.

Keywords: Hepatectomy; Histopathological growth patterns; Liver metastases; Prognosis; Survival.

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Conflict of interest statement

Declarations. Ethical approval: All analyses were based on previous published studies, thus no ethical approval and patient consent are required. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

References

    1. Tsilimigras DI, Brodt P, Clavien PA, Muschel RJ, D’Angelica MI, Endo I, Parks RW, Doyle M, de Santibañes E, Pawlik TM (2021) Liver metastases. Nat Rev Disease Primers 7(1):27. https://doi.org/10.1038/s41572-021-00261-6 - DOI - PubMed
    1. Cervantes A, Adam R, Roselló S, Arnold D, Normanno N, Taïeb J, Seligmann J, De Baere T, Osterlund P, Yoshino T, Martinelli E (2023) Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol 34(1):10–32. https://doi.org/10.1016/j.annonc.2022.10.003 - DOI - PubMed
    1. Fairweather M, Swanson R, Wang J, Brais LK, Dutton T, Kulke MH, Clancy TE (2017) Management of neuroendocrine tumor liver metastases: long-term outcomes and prognostic factors from a large prospective database. Ann Surg Oncol 24(8):2319–2325. https://doi.org/10.1245/s10434-017-5839-x - DOI - PubMed
    1. Vermeulen PB, Colpaert C, Salgado R, Royers R, Hellemans H, Van Den Heuvel E, Goovaerts G, Dirix LY, Van Marck E (2001) Liver metastases from colorectal adenocarcinomas grow in three patterns with different angiogenesis and desmoplasia. J Pathol 195(3):336–342. https://doi.org/10.1002/path.966 - DOI - PubMed
    1. Stessels F, Van den Eynden G, Van der Auwera I, Salgado R, Van den Heuvel E, Harris AL, Jackson DG, Colpaert CG, van Marck EA, Dirix LY, Vermeulen PB (2004) Breast adenocarcinoma liver metastases, in contrast to colorectal cancer liver metastases, display a non-angiogenic growth pattern that preserves the stroma and lacks hypoxia. Br J Cancer 90(7):1429–1436. https://doi.org/10.1038/sj.bjc.6601727 - DOI - PubMed - PMC

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