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Review
. 2025 Jul 15;37(4-6):29.
doi: 10.1007/s44445-025-00036-9.

Biomineralization of dental tissues with natural drugs: a comprehensive review

Yuguang Liu  1 , Ziqi Wu  2
Affiliations
Review

Biomineralization of dental tissues with natural drugs: a comprehensive review

Yuguang Liu et al. Saudi Dent J. .

Abstract

This narrative review systematically examines the emerging role of natural bioactive substances in dental tissue biomineralization. Through comprehensive analysis of peer-reviewed literature (2000-2024) identified via PubMed, Web of Science, and Scopus using keywords including 'natural drugs,' 'biomineralization,' and 'dental restoration,' we evaluate three key aspects: (1) the limitations of current restorative materials (composite resins, adhesives); (2) the mechanisms of natural compounds (collagen protection, mineral deposition, demineralization inhibition); and (3) clinical translation challenges. Our analysis reveals that plant-derived flavonoids, polyphenols, and bioactive peptides show particular promise for enhancing remineralization while addressing toxicity concerns. The review concludes by proposing a research framework for developing next-generation bioactive restorative materials, highlighting knowledge gaps in long-term stability and standardized protocols.

Keywords: Adhesives; Collagen matrix; Composite resins; Natural bioactive substances; Polyphenols; Remineralization.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: This review does not cover human or animal experiments. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests.

Figures

Fig.1
Fig.1
PCCP pathway and PILP pathway for tooth remineralization (image source with permission: Yang et al. 2024a)
Fig.2
Fig.2
Chitosan mineralization properties and tissue MMPs degradation function (image source with permission: Hu et al. 2024b)
Fig.3
Fig.3
Antimicrobial properties of EGCG (image source with permission: Lee et al. 2024a)
See this image and copyright information in PMC

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