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. 2025 Jul;32(4):463-467.
doi: 10.1007/s40292-025-00727-8. Epub 2025 Jul 15.

Association Between Elevated Lipoprotein(a) and Diastolic Dysfunction: A Retrospective Cohort Study

Hesham Sheashaa #  1 , Kamal Awad #  1 , Arshad Mohammed  2 , Juan M Farina  1 , Mohammed Tiseer Abbas  1 , Milagros Pereyra Pietri  1 , Isabel G Scalia  1 , Nima Baba Ali  1 , Nadera N Bismee  1 , Sogol Attaripour Esfahani  1 , Omar Ibrahim  1 , Fatmaelzahraa Abdelfattah  1 , Ahmed K Mahmoud  1 , Steven J Lester  1 , David Simper  1 , Chadi Ayoub  1 , Reza Arsanjani  3
Affiliations

Association Between Elevated Lipoprotein(a) and Diastolic Dysfunction: A Retrospective Cohort Study

Hesham Sheashaa et al. High Blood Press Cardiovasc Prev. 2025 Jul.

Abstract

Introduction: Lipoprotein(a) [Lp(a)] has been linked to myocardial fibrosis and endothelial dysfunction, proposed mechanisms for diastolic dysfunction (DD). This study assessed the association between elevated Lp(a) (≥ 50 mg/dL) and DD in patients with preserved ejection fraction (EF).

Aim: We analyzed 1492 adults (median age59) with an Lp(a) measurement and echocardiogram (1997-2024).

Methods: Diastolicdysfunction required ≥ 3 abnormal echo parameters, as per recent guidelines. Logisticregression adjusting for potential confounders was performed.

Results: Seventy-sevenpatients (5.1%) had DD. Lp(a) ≥ 50 mg/dL was not associated with DD [adjusted oddsratio (aOR): 0.89, 95% confidence interval (CI): 0.49-1.54]. However, age (aOR:1.03, p = 0.026), hypertension (aOR: 1.83, p = 0.042), diabetes mellitus (aOR: 2.43, p =0.002), and cardiovascular (CV) diseases (aOR: 1.90, p = 0.043) were associated withDD, while statin therapy was associated with reduced risk (aOR: 0.51, p = 0.016).

Conclusions: In the setting of preserved EF, Lp(a) was not associated with DD,emphasizing management of traditional CV risks.

Keywords: Cardiovascular; Cholesterol; Diastolic dysfunction; Lipoprotein.

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Conflict of interest statement

Declarations. Conflict of interest: The authors have no competing interests to declare that are relevant to the content of this article. Ethical approval: The study was approved by the Mayo Clinic Institutional Review Board, with informed consent waived due to its retrospective nature.

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