Mitochondrial dysfunction as the missing mechanistic link between hand grip strength and CKD progression

Affiliations

¹ Department of Urology, Chang Gung Memorial Hospital-Linkou, Chang Gung University School of Medicine, 5 Fu-Shing Street, Guishan, Taoyuan, 333, Taiwan. laserep@cgu.edu.tw.
² Department of Family Medicine, Linkou Chang Gung Memorial Hospital, and School of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan.
³ Department of Urology, Chang Gung Memorial Hospital-Linkou, Chang Gung University School of Medicine, 5 Fu-Shing Street, Guishan, Taoyuan, 333, Taiwan.

Comment

Yu-Hsiang Lin et al. Int Urol Nephrol. 2026 Jan.

. 2026 Jan;58(1):359-360.

doi: 10.1007/s11255-025-04665-1. Epub 2025 Jul 15.

¹ Department of Urology, Chang Gung Memorial Hospital-Linkou, Chang Gung University School of Medicine, 5 Fu-Shing Street, Guishan, Taoyuan, 333, Taiwan. laserep@cgu.edu.tw.
² Department of Family Medicine, Linkou Chang Gung Memorial Hospital, and School of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan.
³ Department of Urology, Chang Gung Memorial Hospital-Linkou, Chang Gung University School of Medicine, 5 Fu-Shing Street, Guishan, Taoyuan, 333, Taiwan.

No abstract available

Conflict of interest statement

Declarations. Conflict of interests: The authors declare no competing interests.

The association between hand grip strength and chronic kidney disease progression: insights from SMP-CKD studies.
Huang Q, Chen L, Ouyang W, Jie XN, Fu LZ, Tang F, Wang J, Wu Y, Liu X. Huang Q, et al. Int Urol Nephrol. 2025 Oct;57(10):3427-3438. doi: 10.1007/s11255-025-04457-7. Epub 2025 May 1. Int Urol Nephrol. 2025. PMID: 40310508

1. Huang Q, Chen L, Ouyang W, Jie X-n, Fu L-z, Tang F et al (2025) The association between hand grip strength and chronic kidney disease progression: insights from SMP-CKD studies. Int Urol Nephrol. https://doi.org/10.1007/s11255-025-04457-7 - DOI - PubMed - PMC
1. Suomalainen A, Nunnari J (2024) Mitochondria at the crossroads of health and disease. Cell 187:2601–2627. https://doi.org/10.1016/j.cell.2024.04.037 - DOI - PubMed
1. Buondonno I, Sassi F, Cattaneo F, D’Amelio P (2022) Association between immunosenescence, mitochondrial dysfunction and frailty syndrome in older adults. Cells 12:44. https://doi.org/10.3390/cells12010044 - DOI - PubMed - PMC
1. Lin Y-H, Lin K-J, Wu C-T (2025) Revisiting the complex interactions in nocturnal polyuria: insights on OSA, ADH and ANP. Nat Rev Urol. https://doi.org/10.1038/s41585-025-01028-4 - DOI - PubMed
1. Lin YH, Wu CT, Juang HH (2024) Exploring the complex interplay: BPH, nocturia, and aging male health. World J Urol 42:105. https://doi.org/10.1007/s00345-024-04849-x - DOI - PubMed