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Case Reports
. 2025 Aug:133:111605.
doi: 10.1016/j.ijscr.2025.111605. Epub 2025 Jul 3.

Metastatic carcinoma of the cervix with unexpected ovarian involvement: A rare case report and review of the literature

Soheila Aminimoghaddam  1 , Niloufar Sarchami  1 , Marzieh Mohammadi  2
Affiliations
Case Reports

Metastatic carcinoma of the cervix with unexpected ovarian involvement: A rare case report and review of the literature

Soheila Aminimoghaddam et al. Int J Surg Case Rep. 2025 Aug.

Abstract

Introduction and importance: Ovarian metastasis from cervical carcinoma (CC) is rare. As adenocarcinomas tend to develop within the endocervix, they may be hidden in Pap tests and have a normal Colposcopic appearance. Only a limited number of Ovarian metastases from CC are reported in the literature, and various aspects of this involvement still need to be clarified.

Presentation: In this study, we reported a case of unexpected ovarian metastatic cervical cancer in a 57-year-old female. The uniqueness of the present case was the large size of the metastatic ovarian mass, which led to ureter compression from the AC and the good response to chemoradiotherapy. Unlike the previously reported cases in which the ureter was obstructed at the ureter-bladder junction(trigone), in our case, ureter obstruction occurred at the level of the pelvic brim.

Clinical discussion: Even though ovarian metastasis of cervical cancer is rare, chemoradiotherapy (CRT) manifests a good response with no remnant cervical mass observed in the surgery, which is compatible with the result of a normal Positron emission tomography scan (PET).

Conclusion: Cervical adenocarcinoma can often be diagnosed at very late stages, presenting with large ovarian masses and symptoms of ureter compression. This highlights a lack of awareness regarding appropriate cervical cancer screening tests. Moreover, there is a need for appropriate following imaging methods to differentiate pelvic masses and lymph nodes.

Keywords: Cervical adenocarcinoma; Ovarian involvement; Positron emission tomography scan.

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Conflict of interest statement

Declaration of competing interest There are no conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1
Pathological findings confirming HPV associated adenocarcinoma in the sample before surgery.
Fig. 2
Fig. 2
PET scan shows no other distant metastasis.
Fig. 3
Fig. 3
Preoperative radiographic findings.
Fig. 4
Fig. 4
Photographs of the extracted mass. (A): cervix; (B): ovarian involvement.
Fig. 5
Fig. 5
(a, b) Cervical pathology (×40); (b) in myxoid patterns, epithelioid tumor cells proliferated in loosely cohesive storiform arrangement (×10); (c) Necrotic ovarian wall (×40).
See this image and copyright information in PMC

References

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