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Case Reports
. 2025 Jul-Sep;47(3):103939.
doi: 10.1016/j.htct.2025.103939. Epub 2025 Jul 15.

Onset of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis triggered by sudden reactivation of asymptomatic latent Epstein-Barr virus infection

Masanari Mizuki  1 , Takuya Terakawa  2 , Yuka Umeki  1 , Hitomi Matsunaga  1 , Yoshiki Matsuoka  1 , Wataru Nakahara  1 , Shogo Matsui  1 , Mako Ikeda  1 , Kodai Ueshima  1 , Yuya Hayasaka  1 , Nayu Matsuoka  1 , Yuma Tada  3 , Takahiro Matsui  4 , Kazumasa Oka  5 , Shuji Ueda  6
Affiliations
Case Reports

Onset of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis triggered by sudden reactivation of asymptomatic latent Epstein-Barr virus infection

Masanari Mizuki et al. Hematol Transfus Cell Ther. 2025 Jul-Sep.
No abstract available

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Conflict of interest statement

Conflicts of interest The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Positron emission tomography-computed tomography demonstrated pathological 18F-fluorodeoxyglucose uptake in mediastinal lymph nodes (a, d), abdominal lymph nodes (b, d), spleen (b, c, d), liver mass (b, c), and systemic bone (a, b, c, d).
Figure 2
Figure 2
Histopathological findings of liver mass biopsy were consistent with hemophagocytic lymphohistiocytosis. Hematoxylin and eosin stain (a), immunohistochemical stain for CD68 (b), CD3 (c), CD20 (d), CD4 (e), CD8 (f), CD56 (g), and in-situ hybridization for Epstein-Barr virus-encoded early RNA (h). HE: hematoxylin and eosin; EBER: Epstein-Barr virus-encoded early RNA.
See this image and copyright information in PMC

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