Sinonasal intestinal-type adenocarcinoma: Multi-institutional retrospective analysis based on 440 patients with long-term follow-up

Iacopo Dallan¹, Giacomo Fiacchini², Domenico Tricò³, Matteo Barucco⁴, Mario Turri-Zanoni⁵, Marco Ferrari⁶, Lorena Di Girolami², Gloria Schiavo⁷, Enzo Emanuelli⁸, Davide Mattavelli⁹, Alberto Schreiber¹⁰, Cesare Piazza⁹, Christos Georgalas¹¹, Thibaut van Zele¹², Anne-Sophie Eeckels¹², Paolo Battaglia⁵, Maurizio Bignami¹³, Marinella Molteni¹⁴, Giacomo Sollini¹⁵, Paolo Castelnuovo¹⁶, Ernesto Pasquini¹⁵, Piero Nicolai⁶

Affiliations

¹ Skull Base and Rhino-orbital Surgery Unit, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy.
² Otolaryngology, Audiology and Phoniatric Operative Unit, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, Azienda Ospedaliero-Universitaria Pisana (AOUP), University of Pisa, Pisa, Italy.
³ Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
⁴ Skull Base and Rhino-orbital Surgery Unit, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Otolaryngology, Audiology and Phoniatric Operative Unit, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, Azienda Ospedaliero-Universitaria Pisana (AOUP), University of Pisa, Pisa, Italy. Electronic address: matteobarucco@gmail.com.
⁵ Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Lariana, Como, Italy.
⁶ Section of Otorhinolaryngology - Head and Neck Surgery, Department of Neuroscience (DNS), University of Padova, Padova, Italy; Unit of Otorhinolaryngology - Head and Neck Surgery, "Azienda Ospedale Università di Padova", Padova, Italy.
⁷ Section of Otorhinolaryngology - Head and Neck Surgery, Department of Neuroscience (DNS), University of Padova, Padova, Italy.
⁸ Otolaryngology Unit, Ca' Foncello Hospital, Local Health Unit N.2 "Marca Trevigiana", Treviso, Italy.
⁹ Unit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili Brescia, Brescia, Italy; Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, University of Brescia, Brescia, Italy.
¹⁰ Unit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili Brescia, Brescia, Italy.
¹¹ Department of Head, Neck and Skull Base Surgery, Hygeia Hospital, Athens, Greece.
¹² Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium.
¹³ Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Sette Laghi, Varese, Italy.
¹⁴ Department of Radiotherapy, "ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi", Varese, Italy.
¹⁵ ENT Unit, Bellaria Hospital, Azienda USL Bologna, Bologna, Italy.
¹⁶ Division of Otolaryngology, Department of Biotechnology and LifeSciences, University of Insubria, Ospedale di Circolo e Fondazione Macchi, Varese, Italy.

PMID: 40669387
DOI: 10.1016/j.ejca.2025.115623

Multicenter Study

Sinonasal intestinal-type adenocarcinoma: Multi-institutional retrospective analysis based on 440 patients with long-term follow-up

Iacopo Dallan et al. Eur J Cancer. 2025.

. 2025 Aug 26:226:115623.

doi: 10.1016/j.ejca.2025.115623. Epub 2025 Jul 10.

Authors

Affiliations

¹ Skull Base and Rhino-orbital Surgery Unit, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy.
² Otolaryngology, Audiology and Phoniatric Operative Unit, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, Azienda Ospedaliero-Universitaria Pisana (AOUP), University of Pisa, Pisa, Italy.
³ Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
⁴ Skull Base and Rhino-orbital Surgery Unit, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Otolaryngology, Audiology and Phoniatric Operative Unit, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, Azienda Ospedaliero-Universitaria Pisana (AOUP), University of Pisa, Pisa, Italy. Electronic address: matteobarucco@gmail.com.
⁵ Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Lariana, Como, Italy.
⁶ Section of Otorhinolaryngology - Head and Neck Surgery, Department of Neuroscience (DNS), University of Padova, Padova, Italy; Unit of Otorhinolaryngology - Head and Neck Surgery, "Azienda Ospedale Università di Padova", Padova, Italy.
⁷ Section of Otorhinolaryngology - Head and Neck Surgery, Department of Neuroscience (DNS), University of Padova, Padova, Italy.
⁸ Otolaryngology Unit, Ca' Foncello Hospital, Local Health Unit N.2 "Marca Trevigiana", Treviso, Italy.
⁹ Unit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili Brescia, Brescia, Italy; Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, University of Brescia, Brescia, Italy.
¹⁰ Unit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili Brescia, Brescia, Italy.
¹¹ Department of Head, Neck and Skull Base Surgery, Hygeia Hospital, Athens, Greece.
¹² Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium.
¹³ Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Sette Laghi, Varese, Italy.
¹⁴ Department of Radiotherapy, "ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi", Varese, Italy.
¹⁵ ENT Unit, Bellaria Hospital, Azienda USL Bologna, Bologna, Italy.
¹⁶ Division of Otolaryngology, Department of Biotechnology and LifeSciences, University of Insubria, Ospedale di Circolo e Fondazione Macchi, Varese, Italy.

PMID: 40669387
DOI: 10.1016/j.ejca.2025.115623

Abstract

Background: Sinonasal intestinal-type adenocarcinoma (ITAC) is the most common nasoethmoidal cancer in European countries. Subtypes and other prognostic factors/parameters are known to be associated with prognosis.

Methods: We performed a retrospective analysis of prognostic factors associated with overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS) in patients affected by histologically-proven sinonasal ITAC, managed with an endoscopic surgery-centered protocol in 6 European centers. A prognostic study with multivariable analysis was performed.

Results: Mean follow up was 74 months. 5-year CSS was 81.7 %, varying substantially according to the histologic subtype, ranging from 94.8 % for well differentiated tubulo-papillary subtype to 32.7 % for signet-ring cell ITAC. Whole group 5-year recurrence rate was 30.8 %, ranging from 18.7 % for well differentiated tubulo-papillary subtype to 73.8 % for signet-ring cell ITAC.

Conclusion: Considering ITAC as a single entity is no longer advisable, as different subtypes carry remarkably different prognosis. Until novel, standardized biomarkers will be available, ITAC management needs to be customized upon several factors, with histopathology-based subtyping being exceedingly relevant.

Keywords: Endoscopic surgery; Histotype; Prognosis; Recurrence; Sinonasal intestinal-type adenocarcinoma; Sinonasal malignancies; Survival.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Sinonasal intestinal-type adenocarcinoma: Multi-institutional retrospective analysis based on 440 patients with long-term follow-up

Affiliations

Sinonasal intestinal-type adenocarcinoma: Multi-institutional retrospective analysis based on 440 patients with long-term follow-up

Authors

Affiliations

Abstract

Conflict of interest statement

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LinkOut - more resources

Full Text Sources