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. 2025 Jun 15;17(6):4723-4732.
doi: 10.62347/GRGQ7128. eCollection 2025.

Effect of interleukin-6 and interleukin-8 levels on pathogenic bacteria types in patients with advanced lung cancer and pulmonary infection during chemotherapy

Xiaodan Zheng  1 , Hongyun Lan  2 , Yuhai Hu  1 , Peifu Tian  1
Affiliations

Effect of interleukin-6 and interleukin-8 levels on pathogenic bacteria types in patients with advanced lung cancer and pulmonary infection during chemotherapy

Xiaodan Zheng et al. Am J Transl Res. .

Abstract

Objective: To investigate the levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) in patients with advanced lung cancer complicated by pulmonary infection during chemotherapy and their effects on the type of pathogenic bacteria.

Method: We retrospectively analyzed the clinical data of 196 patients from Wuhan Hankou Hospital (January 2021-June 2024). The incidence of pulmonary infection was assessed, and the levels of IL-6 and IL-8 were compared across different infection severities and pathogenic bacteria types. Spearman correlation analysis was used to determine associations, and logistic regression was performed to identify factors influencing different pathogenic bacteria infections.

Result: The lung infection rate was 24.49% (48/196). Pathogenic bacteria included 36 strains (64.29%) of Gram-negative bacteria (G-) and 20 strains (35.71%) of Gram-positive bacteria (G+). The levels of IL-6 and IL-8 were significantly higher in infected patients than in uninfected patients (P < 0.05). These levels increased with the severity of infection and were positively correlated with the degree of infection. Elevated IL-6 and IL-8 levels were identified as independent risk factors for Gram-negative bacterial (G-) infections in patients with pulmonary infection. The combined AUC, sensitivity, and specificity of IL-6 and IL-8 were 0.925, 81.80%, and 93.33%, respectively.

Conclusion: In patients with advanced-stage lung cancer undergoing chemotherapy, elevated IL-6 and IL-8 levels were closely associated with pulmonary infection severity. Detection of these cytokines may help differentiate the types of pathogenic bacteria causing lung infections.

Keywords: Middle-late stage lung cancer; interleukin-6; interleukin-8; lung infection; pathogenic bacteria.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Flow chart of patient selection.
Figure 2
Figure 2
Scatter plot of the relationship between the degree of pulmonary infection, IL-6, and IL-8. Note: (A) Relationship between the degree of pulmonary infection and IL-6; (B) Relationship between the degree of pulmonary infection and IL-8.
Figure 3
Figure 3
Distribution of pathogenic bacteria in patients with pulmonary infection. Note: G-: Gram-negative bacteria; G+: Gram-positive bacteria.
Figure 4
Figure 4
ROC curve.
See this image and copyright information in PMC

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