Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jul 15;41(4):e70108.
doi: 10.1002/joa3.70108. eCollection 2025 Aug.

Arrhythmogenic mitral valve prolapse-a systematic review of ventricular arrhythmia and sudden cardiac death outcomes before and after mitral valve surgery

James N Cameron  1   2 , Nigel Sutherland  3 , Chee Loong Chow  2   3 , Hui-Chen Han  4 , Matias Yudi  1   2 , Rajiv Mahajan  5   6 , Anand Ganesan  7 , Avi Sabbag  8 , Kristina H Haugaa  9   10 , Jai Raman  11 , Prashanthan Sanders  12 , Omar Farouque  1   2 , Han S Lim  1   2
Affiliations

Arrhythmogenic mitral valve prolapse-a systematic review of ventricular arrhythmia and sudden cardiac death outcomes before and after mitral valve surgery

James N Cameron et al. J Arrhythm. .

Abstract

Background: Several autopsy and observational studies have investigated the link between mitral valve prolapse (MVP) and sudden cardiac death (SCD) given the well accepted yet rare occurrence of ventricular arrhythmias (VA). Whether surgical intervention for arrhythmogenic MVP (aMVP) reduces VA and SCD risk remains unknown.

Methods: A systematic literature review was conducted using the PubMed database in December 2024. Studies documented in English were included if patients had undergone mitral valve (MV) surgery (MVS; repair or replacement) for MVP with documented rates of VA or SCD pre- and postintervention.

Results: Sixteen identified studies (8 cohort and 8 case studies) comprised 1233 patients (receiving medical or surgical treatment) with a pooled mean age of 61.5 years and 41.9% being female. A total of 657 MVP patients underwent MVS. Seven cohort studies reported rates of VA pre- and postintervention, with six of these and all case studies reporting a significant reduction. The remaining cohort study reported a reduction in SCD.

Conclusions: This systematic review indicates a reduction in VA following current guideline-directed MVS for MVP. However, a residual risk of VA and SCD may remain postintervention.

Keywords: mitral valve prolapse; mitral valve surgery; percutaneous mitral valve repair; sudden cardiac death; ventricular arrhythmia.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
PRISMA search algorithm.
See this image and copyright information in PMC

References

    1. Basso C, Calabrese F, Corrado D, Thiene G. Postmortem diagnosis in sudden cardiac death victims: macroscopic, microscopic and molecular findings. Cardiovasc Res. 2001;50:290–300. 10.1016/s0008-6363(01)00261-9 - DOI - PMC - PubMed
    1. Essayagh B, Sabbag A, Antoine C, Benfari G, Batista R, Yang LT, et al. The mitral annular disjunction of mitral valve prolapse. J Am Coll Cardiol Img. 2021;14:2073–2087. 10.1016/j.jcmg.2021.04.029 - DOI - PubMed
    1. Han HC, Calafiore P, Teh AW, Farouque O, Lim HS. Arrhythmic mitral annulus disjunction and mitral valve prolapse: components of the same clinical Spectrum? J Am Coll Cardiol. 2019;73:739. 10.1016/j.jacc.2018.10.090 - DOI - PubMed
    1. Han HC, Ha FJ, Teh AW, Calafiore P, Jones EF, Johns J, et al. Mitral valve prolapse and sudden cardiac death: a systematic review. J Am Heart Assoc. 2018;7:e010584. 10.1161/jaha.118.010584 - DOI - PMC - PubMed
    1. Han HC, Parsons SA, Teh AW, Sanders P, Neil C, Leong T, et al. Characteristic histopathological findings and cardiac arrest rhythm in isolated mitral valve prolapse and sudden cardiac death. J Am Heart Assoc. 2020;9:e015587. 10.1161/jaha.119.015587 - DOI - PMC - PubMed

LinkOut - more resources