Long-term efficacy and improved overall survival of lorlatinib in anaplastic lymphoma kinase-rearranged lung cancer: is cure a dream or a reality?
- PMID: 40673079
- PMCID: PMC12261235
- DOI: 10.21037/tlcr-2025-694
Long-term efficacy and improved overall survival of lorlatinib in anaplastic lymphoma kinase-rearranged lung cancer: is cure a dream or a reality?
Keywords: Non-small cell lung cancer (NSCLC); anaplastic lymphoma kinase-rearrangement (ALK-rearrangement); lorlatinib; tyrosine kinase inhibitor (TKI).
Conflict of interest statement
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-2025-694/coif). The authors have no conflicts of interest to declare.
Comment on
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Final Overall Survival and Long-Term Safety of Lorlatinib in Patients With ALK-Positive NSCLC From the Pivotal Phase 2 Study: A Brief Report.J Thorac Oncol. 2025 Apr;20(4):513-520. doi: 10.1016/j.jtho.2024.11.021. Epub 2024 Nov 22. J Thorac Oncol. 2025. PMID: 39581380 Clinical Trial.
References
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- Lin JJ, Horan JC, Tangpeerachaikul A, et al. NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations. Cancer Discov 2024;14:2367-86. 10.1158/2159-8290.CD-24-0231 - DOI - PMC - PubMed
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