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. 2025 Aug 12;105(3):e213901.
doi: 10.1212/WNL.0000000000213901. Epub 2025 Jul 17.

Incidence and Prognosis of Pediatric Stroke in Denmark: A Nationwide Population-Based Study

Julie Brix Bindslev  1   2 , Jan Brink Valentin  3 , Søren P Johnsen  3 , John Hauerberg  4 , Klaus Hansen  1   5 , Christina Engel Hoei-Hansen  2   5 , Thomas Truelsen  1   5
Affiliations

Incidence and Prognosis of Pediatric Stroke in Denmark: A Nationwide Population-Based Study

Julie Brix Bindslev et al. Neurology. .

Abstract

Background and objectives: The aim of this study was to estimate incidence rates, changes in incidence rates, and prognosis of pediatric stroke in Denmark from 2013 to 2020.

Methods: Through a nationwide register, we identified all children (age 29 days-17 years) registered with a first-ever stroke or stroke-related diagnosis between 2013 and 2020. Possible stroke events were validated by medical record review. Age-adjusted incidence rates and absolute changes in incidence rates were estimated by Poisson regression analysis. Kaplan-Meier analysis was used to estimate 30-day, 1-year, and 5-year cumulative mortality risks.

Results: Between 2013 and 2020, the age-adjusted stroke incidence rate increased in male individuals while no change was noted in female individuals. The trend observed in male individuals was driven by the increased incidence rate of arterial ischemic stroke (AIS) (yearly absolute change per 100,000 person-years: 0.14, 95% CI 0.018-0.26). The 30-day, 1-year, and 5-year cumulative mortality risks were 7.7% (95% CI 4.2-11.2), 10.0% (95% CI 6.0-13.9), and 11.0% (95% CI 6.8-15.2), respectively. Mortality risk remained stable over time (p value = 0.77). Among children alive at follow-up, moderate-severe neurologic impairment was present in 20.2% with AIS and 23.1% with intracerebral hemorrhage.

Discussion: From 2013 through 2020, the age-adjusted incidence rate of pediatric stroke increased in male individuals while remaining stable in female individuals. Morbidity and mortality after stroke were substantial, highlighting the need for further improvements in pediatric stroke management.

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Conflict of interest statement

The authors report no relevant disclosures. Go to Neurology.org/N for full disclosures.

Figures

Figure
Figure. Cumulative Mortality Risk According to Stroke Subtype and Follow-Up Time
aIncluding children with AIS, ICH, stroke due to cerebral venous thrombosis, and subarachnoid hemorrhage. In 33.3%, the registered cause of death was cerebrovascular disease, including stroke. AIS = arterial ischemic stroke; ICH = intracerebral hemorrhage.
See this image and copyright information in PMC

References

    1. Feigin VL, Abate MD, Abate YH, et al. Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol. 2024;23(10):973-1003. doi: 10.1016/s1474-4422(24)00369-7 - DOI - PMC - PubMed
    1. Sun H, Ma B, Jin C, et al. Global, regional, and national burdens of stroke in children and adolescents from 1990 to 2019: a population-based study. Stroke. 2024;55(6):1543-1553. doi: 10.1161/STROKEAHA.123.044827 - DOI - PubMed
    1. Gandhi SK, McKinney JS, Sedjro JE, et al. Temporal trends in incidence and long-term case fatality of stroke among children from 1994 to 2007. Neurology. 2012;78(24):1923-1929. doi: 10.1212/WNL.0b013e318259e25c - DOI - PubMed
    1. Sacco RL, Kasner SE, Broderick JP, et al. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(7):2064-2089. doi: 10.1161/STR.0b013e318296aeca - DOI - PMC - PubMed
    1. RStudio Team. RStudio. Integrated Development for R. RStudio, PBC; 2020. rstudio.com/