Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Mar;20(1):65-71.
doi: 10.26574/maedica.2025.20.1.65.

Evidence for Furthermore Psychological Disorders in Women with PCOS and the Relation to Hyperandrogenemia and Insulin Resistance: a Systematic Review

Sofia Thomaidi  1 , Sophia Kalantaridou  2 , George Papaioannou  2 , Georgios Valsamakis  3
Affiliations
Review

Evidence for Furthermore Psychological Disorders in Women with PCOS and the Relation to Hyperandrogenemia and Insulin Resistance: a Systematic Review

Sofia Thomaidi et al. Maedica (Bucur). 2025 Mar.

Abstract

Polycystic ovary syndrome (PCOS) is a complex hormone issue that is faced by many women. It usually shows up as high levels of male hormones, problems with ovulation and small cysts on the ovaries. Studies point out that women with PCOS might deal with more mental health problems, although the proof is not rock solid. This summary looks at the ties between PCOS and things like eating disorders, signs of bipolar disorder, autism, schizophrenia and issues with sex. Results suggest that things like insulin resistance and being overweight might add to feeling mentally upset. Also, a diet causing long-term inflammation may make anxiety and stress worse.

PubMed Disclaimer

Conflict of interest statement

None declared.

Figures

FIGURE 1.
FIGURE 1.
PRISMA flow diagram
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Azziz R. Polycystic Ovary Syndrome. Obstet Gynecol . 2018;132:321–336. - PubMed
    1. Cooney LG, Lee I, Sammel MD, Dokras A. High prevalence of moderate and severe depressive and anxiety symptoms in polycystic ovary syndrome: A systematic review and meta-analysis. Hum Reprod . 2017;32:1075–1091. - PubMed
    1. Hollinrake E, Abreu A, Maifeld M, et al. Increased risk of depressive disorders in women with polycystic ovary syndrome. Fertil Steril . 2007;87:1369–1376. - PubMed
    1. Keegan A, Liao LM, Boyle M. 'Hirsutism': a psychological analysis. J Health Psychol . 2003;8:327–345. - PubMed
    1. Sadeghi HM, Adeli I, Calina D, et al. Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management and Drug Repurposing. Int J Mol Sci . 2022;23 - PMC - PubMed

LinkOut - more resources