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Case Reports
. 2025 Mar;20(1):132-136.
doi: 10.26574/maedica.2025.20.1.132.

Efficacy of Arthroscopic Surgery in the Management of Synovial Giant Cell Tumors: a Case Report

Affiliations
Case Reports

Efficacy of Arthroscopic Surgery in the Management of Synovial Giant Cell Tumors: a Case Report

Christos Konstantinidis et al. Maedica (Bucur). 2025 Mar.

Abstract

Giant cell tumors of the synovial membrane are benign but locally aggressive lesions that primarily affect synovial joints. Histologically, they are characterized by the proliferation of histiocytes, multinucleated giant cells and prominent hemosiderin deposition. Clinically, patients often experience joint pain, swelling and restricted movement, which can significantly impact their mobility and quality of life. Traditionally, open surgical excision has been the standard approach for managing these tumors. However, advancements in minimally invasive techniques, particularly arthroscopic surgery, have emerged as effective alternatives. Arthroscopy offers several benefits, including reduced postoperative pain, quicker recovery and minimal surgical trauma, while still allowing for complete tumor removal. This article presents a case of a giant cell tumor of the synovial membrane in the knee of a female patient, highlighting the successful use of arthroscopic treatment and the favorable postoperative outcomes. By presenting this case, we aim to emphasize the growing role of arthroscopic intervention in managing these tumors, further supporting its integration into clinical practice.

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Conflict of interest statement

None declared.

Figures

FIGURE 1.
FIGURE 1.
Preoperative anteroposterior and lateral radiographs of the left knee
FIGURE 2.
FIGURE 2.
Preoperative magnetic resonance imaging (MRI), in which the tumor is marked with red arrows: (A) sagittal view; (B) transverse view
FIGURE 3.
FIGURE 3.
Arthroscopic visualization of the well-circumscribed intraarticular nodular mass
FIGURE 4.
FIGURE 4.
Macroscopic appearance of the tumor (3 x 2 x 0.8 cm in size)
FIGURE 5.
FIGURE 5.
Postoperative magnetic resonance imaging (MRI) at one-year follow-up showing no signs of tumor recurrence: (A) sagittal view; (B) transverse view

References

    1. Nau T, Chiari C, Seitz H, et al. Giant-cell. tumor of the synovial membrane: Localized nodular synovitis in the knee joint. Arthroscopy 2000;16:E22. - PubMed
    1. Ansel S, Yan X, Chong P, et al. Tenosynovial giant cell tumor: case report. J Med Case Rep . 2023;17 - PMC - PubMed
    1. Schwartz HS, Unni KK, Pritchard DJ. Pigmented villonodular synovitis. A. retrospective review of affected large joints. Clin Orthop Relat Res 1989:247:243-255. - PubMed
    1. Mavrogenis AF, Igoumenou VG, Megaloikonomos PD, et al. Giant cell tumor of bone revisited. SICOT J . 2017;3 - PMC - PubMed
    1. Abdalla RJ, Cohen M, Nóbrega J, et al. Synovial giant cell tumor of the knee. Rev Bras Ortop . 2015;44:437–440. - PMC - PubMed

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