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Case Reports
. 2025 Jul 3:15:1591475.
doi: 10.3389/fonc.2025.1591475. eCollection 2025.

Case Report: A patient with metastatic bladder cancer in the stomach

Shurong Liu  1 , Junling Zhang  1 , Xin Wang  1
Affiliations
Case Reports

Case Report: A patient with metastatic bladder cancer in the stomach

Shurong Liu et al. Front Oncol. .

Abstract

Metastasis of bladder cancer to the stomach was rarely reported before. We reported a case of a 68-year-old woman with metastatic bladder cancer to the stomach. The patient was diagnosed with epithelial cell carcinoma of the bladder and underwent resection of the bladder, the right ureter and right kidney two years ago. One and a half years later, the enhanced CT examination revealed diffuse thickening of the stomach. Gastroscopy showed the gastric mucosa were swollen, congested and stiff. The biopsy of the EUS-FNA (Endoscopic Ultrasound-Guided Fine Needle Aspiration) showed a high likelihood of bladder epithelial tumors. Then the patient underwent a total gastrectomy and immunohistochemistry of the specimen indicated that her tumor tissue was originated from the bladder. We recommend that clinicians remain vigilant for gastric tumors that are metastases from bladder cancer, especially in patients with a previous primary bladder tumor.

Keywords: biopsy; bladder cancer; digestive tract endoscopy; metastatic tumor; stomach tumor.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The CT, PET-CT and gastroscopic findings of the patient. (A) Contrast enhanced CT of the abdomen showed diffuse thickening of the gastric wall throughout the stomach. (B) PET-CT showed multiple hypermetabolic foci of mesenteric as well as retroperitoneal lymph nodes (locations marked with yellow arrows), which were considered to be metastases of the tumor. (C) Gastroscopy showed congested, edematous thickening of the gastric wall.
Figure 2
Figure 2
Gross specimens of the tumor and result of immunohistochemistry. (A) The stomach specimens. (B) The H&E staining of resected stomach. (C) GATA3 expression in the tissue. (D) CDX-2 expression in the tissue.
Figure 3
Figure 3
Timeline of clinical course and treatment interventions.
See this image and copyright information in PMC

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