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Case Reports
. 2025 Jun 19:41:e02294.
doi: 10.1016/j.idcr.2025.e02294. eCollection 2025.

Early Scedosporium apiospermium infection of a soil-contaminated traumatic injury successfully treated with isavuconazole: A case report

Gabriele Pagani  1 , Francesco Bassani  1   2 , Paola Mirri  3 , Bianca Osnaghi  3 , Elena Delmastro  4 , Stefano Rusconi  1   2
Affiliations
Case Reports

Early Scedosporium apiospermium infection of a soil-contaminated traumatic injury successfully treated with isavuconazole: A case report

Gabriele Pagani et al. IDCases. .

Abstract

Scedosporium apiospermium, a rare fungal pathogen from soil and stagnant water, can cause invasive infections, particularly in immunocompromised patients. An 83-year-old male with a soil-contaminated traumatic wound developed persistent inflammation despite antibiotic therapy. Scedosporium apiospermium was identified, and systemic isavuconazole led to significant wound improvement after eight weeks. This case emphasizes the need to consider fungal infections in traumatic wounds. Isavuconazole was effective and safe, offering a valuable alternative to voriconazole.

Keywords: Isavuconazole; Scedosporium apiospermium; Traumatic injury.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Patient's leg after initial surgical debridement, first outpatient visit.
Fig. 2
Fig. 2
Microscopic examination of isolate.
See this image and copyright information in PMC

References

    1. Lackner M., Hagen F., Meis J.F., et al. Susceptibility and diversity in the therapy-refractory genus scedosporium. Antimicrob Agents Chemother. 2014;58:5877–5885. - PMC - PubMed
    1. Cooley L., Spelman D., Thursky K., et al. Infection with Scedosporium apiospermum and S. prolificans, Australia. Emerg Infect Dis. 2007;13:1170–1177. - PMC - PubMed
    1. Giacobbe D.R., Riccardi N., Vena A., et al. Mould infections of traumatic wounds: a brief narrative review. Infect Dis Ther. 2020;9:1–15. - PMC - PubMed
    1. Alvarez M., Lopez Ponga B., Rayon C., et al. Nosocomial outbreak caused by Scedosporium prolificans (inflatum): four fatal cases in leukemic patients. J Clin Microbiol. 1995;33:3290–3295. - PMC - PubMed
    1. Guerrero A., Torres P., Duran M.T., et al. Airborne outbreak of nosocomial Scedosporium prolificans infection. Lancet. 2001;357:1267–1268. - PubMed

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